What is the distance between Louisville and Buffalo?

Louisville and Buffalo are 482 miles (777 km) apart.

What are the departure and arrival stations when taking the bus from Louisville to Buffalo?

If you're headed to Buffalo from Louisville, chances are that your bus will depart from Louisville Greyhound Bus Station and arrive at Buffalo Airport. These are the most popular pick-up and drop-off locations on this route, but you can find others that could fit better into your travel plans.

Bus Louisville to Buffalo from $139 | Refundable Tickets

Next departures

Next departures for Louisville to Buffalo on November 7
Operated by	Vehicle type	Departure time	Departure location	Trip duration	Arrival time	Arrival location	Recommended	Price and booking link
FlixBus + Greyhound Lines, Inc.		7:30pm	Louisville, KY	20h 45m	4:15pm	Niagara Frontier Transportation Authority	Cheapest
		2:10am	Louisville, KY	14h 5m	4:15pm	Niagara Frontier Transportation Authority	Fastest

Last refresh of the prices: Today at 5:25 PM EST.

Get from Louisville to Buffalo

This route is served by bus only

The journey takes about 20 hours 45 minutes and with fares starting at just $86, it presents an excellent value for a comfortable ride.

2bus per day

20h 45mAverage Duration

483 milesDistance

19kgCO₂ emissions

Compare bus companies

Greyhound

3.5/587,355 reviews

Staff3.6

Timeliness2.9

Cleanliness3.3

Wifi2.4

Greyhound Lines offers the most comprehensive intercity bus services in the United States. They operate a modern, environmentally friendly fleet that serves more than 2400 destinations and carries nearly 16 million passengers annually. When traveling with them, you can expect free WiFi, onboard entertainment, bathrooms, power outlets and decent legroom. One of the great perks of Greyhound is that they connect big cities and smaller towns in the US, where you usually can't get to by train or plane. If you're looking for safe and affordable transportation, Greyhound is a great choice.

Amtrak

4/55,567 reviews

Staff4.7

Timeliness3.8

Cleanliness4.6

Wifi3.6

US bus companies: FlixBus, BlaBlaCar Bus, ALSA, Greyhound, Intercape, Trenitalia, Sindbad

Where are the popular stops in Louisville and Buffalo?

Stops in Louisville

A - Louisville Greyhound Bus Station

Stops in Buffalo

A - Buffalo Airport

B - Transportation Center

C - Exchange Street Station

Frequently asked questions about traveling from Louisville to Buffalo, NY by bus

What is the distance between Louisville and Buffalo?
What are the departure and arrival stations when taking the bus from Louisville to Buffalo?

Find cheapest prices for buses

Price is for a one-way ticket for one passenger and based on past searches.

Best price found

11/04

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11/05

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Today

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11/07

$139

11/08

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11/09

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11/10

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11/11

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The cheapest trip from Louisville to Buffalo, NY was searched and found on Nov 7, 2025 with a price of $139

To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Louisville to Buffalo, NY, as early as possible.

You can expect to pay from $139 to $139 for a bus ticket from Louisville to Buffalo, NY based on the last 2 days. You can expect to find the cheapest price for the trip at $139 which is on 2025-11-07.

Top traveled bus routes

Why choose Busbud?

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Busbud.com makes it easy for you to find, compare and book city-to-city bus tickets, all over the world. We save you the extra trip to the bus station. With Busbud, wherever you go, you have a worldwide bus station within reach and available in your own language and currency. Busbud prides itself on its worldwide partnerships. We make it possible for you to buy tickets with its large network of trustworthy bus partners like Greyhound, Eurolines, ALSA, OUIBUS (BlaBlaBus), National Express and many others.