Next bus departures
| Operated by | Vehicle type | Departure time | Departure location | Trip duration | Arrival time | Arrival location | Recommended | Price and booking link |
|---|---|---|---|---|---|---|---|---|
 | Bus | Knoxville Bus Station | Indianapolis Bus Station | Cheapest | ||||
| Bus | Knoxville Bus Station | Indianapolis Bus Station | Fastest | ||||
Greyhound Lines, Inc. + FlixBus | Bus | Knoxville Bus Station | Downtown Transit Center | No tags |
Last refresh of the prices: Yesterday at 7:12 AM EST.
Get from Knoxville to Indianapolis
The journey takes about 14 hours 15 minutes and with fares starting at just $68, it presents an excellent value for a comfortable ride.
Where are the popular stops in Knoxville and Indianapolis?
Stops in Knoxville
- AKnoxville Area Transit Bus Stop, 100 Kirkwood St, Knoxville, TN 37914, USA
Compare bus companies
Greyhound Lines offers the most comprehensive intercity bus services in the United States. They operate a modern, environmentally friendly fleet that serves more than 2400 destinations and carries nearly 16 million passengers annually. When traveling with them, you can expect free WiFi, onboard entertainment, bathrooms, power outlets and decent legroom. One of the great perks of Greyhound is that they connect big cities and smaller towns in the US, where you usually can't get to by train or plane. If you're looking for safe and affordable transportation, Greyhound is a great choice.
Greyhound Knoxville Indianapolis recent customer reviews
Was a nice experience, will go greyhound again
Kimberly L.
Frequently asked questions about traveling from Knoxville, TN to Indianapolis by bus
Find cheapest prices for buses
Price is for a one-way ticket for one passenger and based on past searches.
The cheapest trip from Knoxville, TN to Indianapolis was searched and found on Nov 24, 2025 with a price of $106To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Knoxville, TN to Indianapolis, as early as possible.
You can expect to pay from $106 to $237 for a bus ticket from Knoxville, TN to Indianapolis based on the last 2 days. You can expect to find the cheapest price for the trip at $119 which is on 2025-11-28.
