Next bus departures
| Operated by | Vehicle type | Departure time | Departure location | Trip duration | Arrival time | Arrival location | Recommended | Price and booking link |
|---|---|---|---|---|---|---|---|---|
 | Bus | Knoxville Bus Station | Indianapolis Bus Station | Cheapest | ||||
| Bus | Knoxville Bus Station | Indianapolis Bus Station | Fastest | ||||
Greyhound Lines, Inc. + FlixBus | Bus | Knoxville Bus Station | Downtown Transit Center | No tags |
Last refresh of the prices: Today at 8:48 AM EST.
Get from Knoxville to Indianapolis
The journey takes about 14 hours 15 minutes, and with fares starting at just $97, it presents an excellent value for a comfortable ride.
Where are the popular stops in Knoxville and Indianapolis?
Stops in Knoxville
- AKnoxville Area Transit Bus Stop, 100 Kirkwood St, Knoxville, TN 37914, USA
Compare bus companies
Based on 87397 reviews, the company was rated 3.5 stars on Busbud. Travellers were especially satisfied with the ticket access and the temperature but often complained with the WiFi. Greyhound ticket prices on this trip start at $97
Greyhound Knoxville Indianapolis recent customer reviews
Was a nice experience, will go greyhound again
Kimberly L.
Frequently asked questions about travelling from Knoxville, TN to Indianapolis by bus
How far is Knoxville from Indianapolis?
The distance between Knoxville and Indianapolis is around 468 km (290 miles).
What are the departure and arrival locations for buses traveling from Knoxville to Indianapolis?
Buses traveling this route start their trip at 100 Kirkwood St, in Knoxville, and end it at Greyhound Amtrak Station, in Indianapolis.
Find cheapest prices for buses
Price is for a one-way ticket for one passenger and based on past searches.
The cheapest trip from Knoxville, TN to Indianapolis was searched and found on Nov 24, 2025 with a price of $153To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Knoxville, TN to Indianapolis, as early as possible.
You can expect to pay from $153 to $342 for a bus ticket from Knoxville, TN to Indianapolis based on the last 2 days. You can expect to find the cheapest price for the trip at $171 which is on 2025-11-28.
