Next bus departures
| Operated by | Vehicle type | Departure time | Departure location | Trip duration | Arrival time | Arrival location | Recommended | Price and booking link |
|---|---|---|---|---|---|---|---|---|
 | Bus | Knoxville Bus Station | Indianapolis Bus Station | Cheapest | ||||
| Bus | Knoxville Bus Station | Indianapolis Bus Station | Fastest | ||||
Greyhound Lines, Inc. + FlixBus | Bus | Knoxville Bus Station | Downtown Transit Center | No tags |
Last refresh of the prices: Last Monday at 22:07 EST.
Get from Knoxville to Indianapolis
The journey takes about 14 hours 15 minutes, and with fares starting at just £53, it presents an excellent value for a comfortable ride.
Where are the popular stops in Knoxville and Indianapolis?
Stops in Knoxville
- AKnoxville Area Transit Bus Stop, 100 Kirkwood St, Knoxville, TN 37914, USA
Compare bus companies
Based on 87403 reviews, the company was rated 3.5 stars on Busbud. Travellers were especially satisfied with the ticket access and the temperature but often complained with the Wi-Fi. Greyhound ticket prices on this trip start at £53
Greyhound Knoxville Indianapolis recent customer reviews
Was a nice experience, will go greyhound again
Kimberly L.
Frequently asked questions about travelling by bus from Knoxville, TN to Indianapolis
Please note that timetables, routes, or operator details shown here may be updated or vary at the time of your journey.
How much is the bus ticket from Knoxville to Indianapolis?
The cheapest coach tickets from Knoxville to Indianapolis start from £53. The average price for this route is around £91. Busbud recommends that you book your tickets in advance for a better chance to get the lowest possible price.
How long is the bus journey from Knoxville to Indianapolis?
The average bus journey time from Knoxville to Indianapolis is 14h 15m, covering a distance of 288 miles. The fastest bus can take you there in 9h 35m and is operated by Greyhound.
Which bus companies service the Knoxville to Indianapolis route?
Several major bus companies operate on this route with 3 buses available per day.
What is the earliest and latest departure time for the bus from Knoxville to Indianapolis?
The earliest bus departs from Knoxville to Indianapolis at 18:10. And the latest bus departs at 19:05.
What are the CO₂ emissions for the bus trip from Knoxville to Indianapolis?
A bus journey from Knoxville to Indianapolis produces an estimated 12 kg of CO₂, making it a highly eco-friendly choice and a mode of travel recommended by Busbud.
Find cheapest prices for buses
Price is for a one-way ticket for one passenger and based on past searches.
The cheapest trip from Knoxville, TN to Indianapolis was searched and found on 28 Nov 2025 with a price of £92To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Knoxville, TN to Indianapolis as early as possible.
