Next bus departures
| Operated by | Vehicle type | Departure time | Departure location | Trip duration | Arrival time | Arrival location | Recommended | Price and booking link |
|---|---|---|---|---|---|---|---|---|
Greyhound Lines, Inc. + FlixBus | Bus | Knoxville Bus Station | The Woodlands - Windvale Center | CheapestFastest | ||||
 | Bus | Knoxville Bus Station | Houston Bus Station | No tags | ||||
Greyhound Lines, Inc. + FlixBus | Bus | Knoxville Bus Station | Downtown Gray & Smith | No tags | ||||
| Bus | Knoxville Bus Station | Houston Bus Station | No tags | ||||
Greyhound Lines, Inc. + FlixBus | Bus | Knoxville Bus Station | Downtown Gray & Smith | No tags |
Last refresh of the prices: Today at 1:32 AM EST.
Get from Knoxville to Houston
The journey takes about 23 hours 55 minutes and with fares starting at just $100, it presents an excellent value for a comfortable ride.
Where are the popular stops in Knoxville and Houston?
Stops in Knoxville
- AKnoxville Area Transit Bus Stop, 100 Kirkwood St, Knoxville, TN 37914, USA
Stops in Houston
- A
Hillcroft Ave & Southwest Freeway
6590 Southwest Fwy, Houston, TX 77074, USA - B2121 Main St, Houston, TX 77002
- C
Harrisburg Greyhound Station
7000 Harrisburg Blvd, Houston, TX 77011, USA - D7011 Harrisburg Blvd, Houston, TX 77011, USA
- E
Clay St & Louisiana St
600-698 Clay St, Houston, TX 77002, USA - F
Lockwood Dr & Harvey Wilson Dr
820 Lockwood Dr, Houston, TX 77002, USA
Compare bus companies
Greyhound Lines offers the most comprehensive intercity bus services in the United States. They operate a modern, environmentally friendly fleet that serves more than 2400 destinations and carries nearly 16 million passengers annually. When traveling with them, you can expect free WiFi, onboard entertainment, bathrooms, power outlets and decent legroom. One of the great perks of Greyhound is that they connect big cities and smaller towns in the US, where you usually can't get to by train or plane. If you're looking for safe and affordable transportation, Greyhound is a great choice.
Greyhound Knoxville Houston recent customer reviews
Got into Atlanta and bus was cancelled set there 22hrs before rerouted on another trip. First time using a bus for travel and will be the last time
Rachelle N.
Facilities were very dirty and passengers were not respectful to the rules. I feel as if the bus should be monitored by one of the greyhound employees while the other is driving. Staff was not very friendly but instead always in a rush.
Louana W.
Was ok but not the best
Anthony F.
Frequently asked questions about traveling from Knoxville, TN to Houston, US by bus
Please note that schedules, routes, or operator details shown here may be updated or vary at the time of your trip.
How much is the bus ticket from Knoxville to Houston?
The cheapest bus tickets from Knoxville to Houston start from $100. The average price for this route is around $191. Busbud recommends that you book your tickets in advance for a better chance to get the lowest possible price.
How long is the bus ride from Knoxville to Houston?
The average bus trip duration from Knoxville to Houston is 23h 55m, covering a distance of 792 miles (1278 km). The quickest bus can get you there in 23h 50m and is operated by Greyhound.
Which bus companies service the Knoxville to Houston route?
Several major train operators operate on this route with 8 trains available per day.
What is the earliest and latest departure time for the bus from Knoxville to Houston?
The earliest bus departs from Knoxville to Houston at 6:10pm. And the latest bus departs at 10:50pm.
What are the CO₂ emissions for the bus trip from Knoxville to Houston?
A bus trip from Knoxville to Houston generates an estimated 32 kg of CO₂, making it a highly eco-friendly travel option and recommended mode of travel by Busbud.
Find cheapest prices for buses
Price is for a one-way ticket for one passenger and based on past searches.
The cheapest trip from Knoxville, TN to Houston, US was searched and found on Dec 5, 2025 with a price of $152To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Knoxville, TN to Houston, US, as early as possible.
You can expect to pay from $152 to $275 for a bus ticket from Knoxville, TN to Houston, US based on the last 2 days. You can expect to find the cheapest price for the trip at $152 which is on 2025-12-05.
