Greyhound Lines offers the most comprehensive intercity bus services in the United States. They operate a modern, environmentally friendly fleet that serves more than 2400 destinations and carries nearly 16 million passengers annually. When traveling with them, you can expect free WiFi, onboard entertainment, bathrooms, power outlets and decent legroom. One of the great perks of Greyhound is that they connect big cities and smaller towns in the US, where you usually can't get to by train or plane. If you're looking for safe and affordable transportation, Greyhound is a great choice.
Greyhound Key West Orlando recent customer reviews
Very hot in the bus and the bus was in no good condition, but the driver did as best as he could...
Flixbus is a European bus operator that offers intercity and bus travel in over 38 countries. Known for their easy-to-spot lime green buses and for offering affordable transportation between cities in Europe and the Americas, Flixbus is a good option for those looking for an affordable, reliable bus company. In their buses, you'll find free WiFi, bathrooms, and power outlets. You can also pay extra to choose your seat and get extra legroom, or even buy a snack or drink onboard directly from the driver. You can reschedule your ticket for a small fee, which varies from $1 to $5, depending on how close you are to the departure date.
Jet Set Express Terminal, 3718 LB Mcleod Rd., 32805 Orlando, FL,, United StatesJet Set Express Terminal
D - Disney World
Disney's All-Star Sports Resort, 1701 West Buena Vista Dr., Orlando, FL 32830
E - International Dr SuperTours Terminal
5419 International Dr, Orlando, FL 32819, USA
F - Seaworld Hotels
10100 International Drive , Orlando, 32821
Frequently asked questions about traveling from Key West to Orlando by bus
How far is Key West from Orlando?
About 276 miles (445 km) separate Key West and Orlando.
What are the departure and arrival stations when taking the bus from Key West to Orlando?
Most of the buses traveling from Key West to Orlando leave from Caroline St and arrive at Orlando Bus Station. These are the main pick-up and drop-off locations on this route, but you can find others that could fit better into your travel plans.
What are the best sights and things to do in Orlando?
Once in Orlando, you can start exploring the city and discover its surroundings. The top sights and things to do are Harry P. Leu Gardens, K1 Speed, John F. Kennedy Space Center, Orlando Wetlands Park and Winter Park.
Find cheapest prices for buses
Price is for a one-way ticket for one passenger and based on past searches.
Best price found
11/17
$75
11/18
$85
Today
$70
11/20
$75
11/21
No data
11/22
No data
11/23
No data
11/24
$70
The cheapest trip from Key West to Orlando was searched and found on Nov 19, 2025 with a price of $70
To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Key West to Orlando, as early as possible.
You can expect to pay from $70 to $85 for a bus ticket from Key West to Orlando based on the last 2 days. You can expect to find the cheapest price for the trip at $70 which is on 2025-11-24.
The cheapest trip from Key West to Orlando was searched and found on Nov 19, 2025 with a price of $70
