Next departures for Karlsruhe to Prague on November 24
Operated by
Vehicle type
Departure time
Departure location
Trip duration
Arrival time
Arrival location
Recommended
Price and booking link
Bus
Südseite Hauptbahnhof
PRG Airport
CheapestFastest
Bus
Südseite Hauptbahnhof
Prague (Central Bus Station Florenc)
No tags
Bus
Südseite Hauptbahnhof
Prague (Central Bus Station Florenc)
No tags
Bus
Südseite Hauptbahnhof
Prague (Central Bus Station Florenc)
No tags
Bus
Südseite Hauptbahnhof
Prague (Central Bus Station Florenc)
No tags
Last refresh of the prices: Yesterday at 11:49 AM CET.
Compare 3 ways to go from Karlsruhe to Prague
We recommend carpooling
Among the sustainable travel choices, the carpool stands out as the good way to reach Prague. The journey takes about 5 hours 10 minutes and with fares starting at just $29, it presents an excellent value for a comfortable ride.
Flixbus is a European bus operator that offers intercity and bus travel in over 38 countries. Known for their easy-to-spot lime green buses and for offering affordable transportation between cities in Europe and the Americas, Flixbus is a good option for those looking for an affordable, reliable bus company. In their buses, you'll find free WiFi, bathrooms, and power outlets. You can also pay extra to choose your seat and get extra legroom, or even buy a snack or drink onboard directly from the driver. You can reschedule your ticket for a small fee, which varies from $1 to $5, depending on how close you are to the departure date.
Based on 11138 reviews, the company was rated 3.7 stars on Busbud. Travelers were especially satisfied with the ticket access and the staff but often complained with the wifi. BlaBlaCar Bus ticket prices on this trip start at $52
Based on 19 reviews, the company was rated 4.2 stars on Busbud. Travelers were especially satisfied with the staff and the seats but often complained with the timeliness. KLR Bus ticket prices on this trip start at $38
LEX CLUB offers 1 daily buses from Karlsruhe to Prague. Though the average price for this trip is $33, you can find tickets starting at $33. The trip between the two cities usually takes about 690.
Frequently asked questions about traveling from Karlsruhe to Prague by bus
What is the travel distance from Karlsruhe to Prague?
Karlsruhe and Prague are 281 miles (453 km) apart.
What are the departure and arrival stations when taking the bus from Karlsruhe to Prague?
The majority of buses traveling from Karlsruhe to Prague start their journey at Südseite Hauptbahnhof and wind up at Florenc. These are the main departure and arrival locations on this route, but you can also find other options that could better fit your plans.
What are the best sights and things to do in Prague?
Once in Prague, you can start exploring the city and discover its surroundings. The top sights and things to do are Bungee Jumping, Casino, Prague Castle and St. Vitus’ Cathedral, KGB Museum and Rudolfinum.
Find cheapest prices for buses
Price is for a one-way ticket for one passenger and based on past searches.
Best price found
11/16
No data
11/17
$36
Today
$27
11/19
No data
11/20
No data
11/21
$35
11/22
No data
11/23
No data
The cheapest trip from Karlsruhe to Prague was searched and found on Nov 18, 2025 with a price of $27
To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Karlsruhe to Prague, as early as possible.
You can expect to pay from $27 to $75 for a bus ticket from Karlsruhe to Prague based on the last 2 days. You can expect to find the cheapest price for the trip at $35 which is on 2025-11-21.
The cheapest trip from Karlsruhe to Prague was searched and found on Nov 18, 2025 with a price of $27
