Next bus departures
| Operated by | Vehicle type | Departure time | Departure location | Trip duration | Arrival time | Arrival location | Recommended | Price and booking link |
|---|---|---|---|---|---|---|---|---|
Greyhound Lines, Inc. + FlixBus | Bus | Jefferson City | Chicago 95Th & Dan Ryan | CheapestFastest | ||||
Greyhound Lines, Inc. + FlixBus | Bus | Jefferson City | Downtown Greyhound Station | No tags | ||||
 | Bus | Jefferson City | 537-517 W. Jackson Blvd | No tags |
Last refresh of the prices: Yesterday at 2:03 PM CST.
Compare 2 ways to go from Jefferson City to Chicago
Among the sustainable travel choices, the train stands out as the good way to reach Chicago. The journey takes about 8 hours 11 minutes and with fares starting at just $49, it presents an excellent value for a comfortable ride.
Compare bus companies
Greyhound Lines offers the most comprehensive intercity bus services in the United States. They operate a modern, environmentally friendly fleet that serves more than 2400 destinations and carries nearly 16 million passengers annually. When traveling with them, you can expect free WiFi, onboard entertainment, bathrooms, power outlets and decent legroom. One of the great perks of Greyhound is that they connect big cities and smaller towns in the US, where you usually can't get to by train or plane. If you're looking for safe and affordable transportation, Greyhound is a great choice.
Frequently asked questions about traveling from Jefferson City, MO to Chicago by bus
Please note that schedules, routes, or operator details shown here may be updated or vary at the time of your trip.
How much is the bus ticket from Jefferson City to Chicago?
The cheapest bus tickets from Jefferson City to Chicago start from $55. The average price for this route is around $71. Busbud recommends that you book your tickets in advance for a better chance to get the lowest possible price.
How long is the bus ride from Jefferson City to Chicago?
The average bus trip duration from Jefferson City to Chicago is 10h 30m, covering a distance of 330 miles (532 km). The quickest bus can get you there in 18h 25m and is operated by Greyhound.
Which bus companies service the Jefferson City to Chicago route?
Several major train operators operate on this route with 4 trains available per day.
What is the earliest and latest departure time for the bus from Jefferson City to Chicago?
The earliest bus departs from Jefferson City to Chicago at 7:15pm. And the latest bus departs at 7:15pm.
What are the CO₂ emissions for the bus trip from Jefferson City to Chicago?
A bus trip from Jefferson City to Chicago generates an estimated 13 kg of CO₂, making it a highly eco-friendly travel option and recommended mode of travel by Busbud.
Find cheapest prices for buses
Price is for a one-way ticket for one passenger and based on past searches.
The cheapest trip from Jefferson City, MO to Chicago was searched and found on Dec 4, 2025 with a price of $82To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Jefferson City, MO to Chicago, as early as possible.
You can expect to pay from $82 to $185 for a bus ticket from Jefferson City, MO to Chicago based on the last 2 days. You can expect to find the cheapest price for the trip at $82 which is on 2025-12-04.
Top traveled bus routes
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Popular bus departures from Jefferson City
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