Bus Tickets from Jefferson City, MO to Chicago

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MonJun 30
from $146
TueJul 1
from $108
WedJul 2
from $129
ThuJul 3
from $101
FriJul 4
from $107
SatJul 5
from $110
SunJul 6
from $100
MonJul 7

Cheap buses leaving Tuesday

One passenger / one way

  • This trip is recommended because it is: Cheapest + Fastest
    Departure time: July 1 at
    Departure city: Jefferson City
    Departure location: Jefferson City
    Arrival time: July 2 at
    Destination city: Chicago
    Destination location: Chicago 95Th & Dan Ryan
    Operated by: Greyhound Lines, Inc.Greyhound Lines, Inc.
    Vehicle: BusDuration:
  • Departure time: July 1 at
    Departure city: Jefferson City
    Departure location: Jefferson City
    Arrival time: July 2 at
    Destination city: Chicago
    Destination location: Downtown Greyhound Station
    Operated by: Greyhound Lines, Inc.Greyhound Lines, Inc.
    Vehicle: BusDuration:
  • Departure time: July 1 at
    Departure city: Jefferson City
    Departure location: Jefferson City
    Arrival time: July 2 at
    Destination city: Chicago
    Destination location: 537-517 W. Jackson Blvd
    Operated by: Greyhound Lines, Inc.Greyhound Lines, Inc.
    Vehicle: BusDuration:

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Compare 2 ways to go from Jefferson City to Chicago.

Bus
Average Price$57 - $164Average Duration19h
13kg CO₂e5 out of 5 stars
Most eco-friendly
Train
Average Price$49 - $141Average Duration8h 11m
48kg CO₂e1 out of 5 stars
CheapestFastest
busbud logoBusbud recommends taking the train from Jefferson City to Chicago

Among the sustainable travel choices, the train stands out as the good way to reach Chicago. The journey takes about 8 hours 11 minutes and with fares starting at just $49, it presents an excellent value for a comfortable ride.

2train per day
8h 11mAverage Duration
$49Cheapest ticket
48kgCO₂ emissions

Bus Jefferson City to Chicago: Trip Overview

Average ticket price$89
Average bus trip duration19h
Number of daily buses3
Earliest bus departure7:15pm
Distance330 miles (532 km)

Jefferson City to Chicago Bus

With Busbud, comparing and booking tickets for a bus from Jefferson City to Chicago is a breeze. Browse through an extensive selection of bus fares and bus schedules to find the best deals.

We make it our job to connect you with the most dependable bus companies that cover bus service from Jefferson City to Chicago.

Whether it is cheap bus tickets or more luxurious buses going to Chicago from Jefferson City, we help you find what you're looking for based on how much of a budget you have.

Frequently asked questions for your trip Jefferson City, MO - Chicago

Find cheapest prices for buses

Price is for a one-way ticket for one passenger and based on past searches.

Best price found
06/26
$110
06/27
$150
Today
$127
06/29
$186
06/30
$138
07/01
$100
07/02
$121
07/03
$104
busbud logoThe cheapest trip from Jefferson City to Chicago was searched and found on Jul 1, 2025 with a price of $100

To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Jefferson City to Chicago, as early as possible.

You can expect to pay from $100 to $188 for a bus ticket from Jefferson City to Chicago based on the last 2 days. You can expect to find the cheapest price for the trip at $100 which is on 2025-07-01.

About Bus Travel

Bus Travel Tips

Meet and talk to locals at the bus stations while traveling from Jefferson City to Chicago.There is no better way to get inside travel information while exploring a new city than to go straight to its people.

From miles long of beauteous natural landscapes to impressive man-crafted sights, you're bound to be in for a visual treat on your bus trip from Jefferson City to Chicago.

Buses are energy-efficient. Carrying a passenger over 100 kms by coach only takes 0.6-0.9 liters of gas. Compare that to the 2.6 liters required by high-speed train, 6.6 liters by airplane and 7.6 liters by gas-powered car, and it's clear that the bus is a more environmentally-conscious option for your bus transportation from Jefferson City to Chicago.

Make a music playlist for your bus ride from Jefferson City to Chicago, and enjoy the scenery to tunes from your own personal soundtrack.

Did you know?

One of the longest bus route in the world goes all the way from Ontario to Alberta in Canada (with the same bus). This trip is 3,435 km or 2,135 miles long and the price is a bit under $100.

Did you know some bus companies in Germany offer to their passenger low-costs snacks and regional beer based on their destination? Prosit!

The average number of passengers on a coach bus is 32 meaning that a bus could replace a minimum of at least 30 cars!

Will you be returning to Jefferson City by bus?

Bus from Jefferson City to Chicago

You can also go to Chicago by train

Train from Jefferson City to Chicago

Why choose Busbud?

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