What is the travel distance from Jefferson City to Chicago?

It's about 531 km (329 miles) from Jefferson City to Chicago.

Bus Jefferson City to Chicago from $82 | Refundable Tickets

Next bus departures

Next departures for Jefferson City to Chicago on November 23
Operated by	Vehicle type	Departure time	Departure location	Trip duration	Arrival time	Arrival location	Recommended
Greyhound Lines, Inc. + FlixBus	Bus	7:15pm	Jefferson City	10h 5m	5:20am	Chicago 95Th & Dan Ryan	CheapestFastest
Greyhound Lines, Inc. + FlixBus	Bus	7:15pm	Jefferson City	10h 30m	5:45am	Downtown Greyhound Station	No tags
	Bus	7:15pm	Jefferson City	18h 55m	2:10pm	537-517 W. Jackson Blvd	No tags

Next departures for Jefferson City to Chicago on November 24
Operated by	Vehicle type	Departure time	Departure location	Trip duration	Arrival time	Arrival location	Recommended
Greyhound Lines, Inc. + FlixBus	Bus	7:15pm	Jefferson City	10h 30m	5:45am	Downtown Greyhound Station	Cheapest
Greyhound Lines, Inc. + FlixBus	Bus	7:15pm	Jefferson City	10h 5m	5:20am	Chicago 95Th & Dan Ryan	Fastest
	Bus	7:15pm	Jefferson City	18h 55m	2:10pm	537-517 W. Jackson Blvd	No tags

Next departures for Jefferson City to Chicago on November 25
Operated by	Vehicle type	Departure time	Departure location	Trip duration	Arrival time	Arrival location	Recommended
Greyhound Lines, Inc. + FlixBus	Bus	7:15pm	Jefferson City	10h 5m	5:20am	Chicago 95Th & Dan Ryan	CheapestFastest
Greyhound Lines, Inc. + FlixBus	Bus	7:15pm	Jefferson City	10h 30m	5:45am	Downtown Greyhound Station	No tags
	Bus	7:15pm	Jefferson City	18h 55m	2:10pm	537-517 W. Jackson Blvd	No tags

Next departures for Jefferson City to Chicago on November 26
Operated by	Vehicle type	Departure time	Departure location	Trip duration	Arrival time	Arrival location	Recommended
Greyhound Lines, Inc. + FlixBus	Bus	7:15pm	Jefferson City	10h 5m	5:20am	Chicago 95Th & Dan Ryan	CheapestFastest
Greyhound Lines, Inc. + FlixBus	Bus	7:15pm	Jefferson City	10h 30m	5:45am	Downtown Greyhound Station	No tags
	Bus	7:15pm	Jefferson City	18h 55m	2:10pm	537-517 W. Jackson Blvd	No tags

Next departures for Jefferson City to Chicago on November 27
Operated by	Vehicle type	Departure time	Departure location	Trip duration	Arrival time	Arrival location	Recommended
Greyhound Lines, Inc. + FlixBus	Bus	7:15pm	Jefferson City	10h 5m	5:20am	Chicago 95Th & Dan Ryan	CheapestFastest
Greyhound Lines, Inc. + FlixBus	Bus	7:15pm	Jefferson City	10h 30m	5:45am	Downtown Greyhound Station	No tags
	Bus	7:15pm	Jefferson City	18h 55m	2:10pm	537-517 W. Jackson Blvd	No tags

Next departures for Jefferson City to Chicago on November 28
Operated by	Vehicle type	Departure time	Departure location	Trip duration	Arrival time	Arrival location	Recommended
Greyhound Lines, Inc. + FlixBus	Bus	7:15pm	Jefferson City	10h 5m	5:20am	Chicago 95Th & Dan Ryan	CheapestFastest
Greyhound Lines, Inc. + FlixBus	Bus	7:15pm	Jefferson City	10h 30m	5:45am	Downtown Greyhound Station	No tags
	Bus	7:15pm	Jefferson City	18h 55m	2:10pm	537-517 W. Jackson Blvd	No tags

Next departures for Jefferson City to Chicago on November 29
Operated by	Vehicle type	Departure time	Departure location	Trip duration	Arrival time	Arrival location	Recommended
Greyhound Lines, Inc. + FlixBus	Bus	7:15pm	Jefferson City	10h 5m	5:20am	Chicago 95Th & Dan Ryan	CheapestFastest
Greyhound Lines, Inc. + FlixBus	Bus	7:15pm	Jefferson City	10h 30m	5:45am	Downtown Greyhound Station	No tags
	Bus	7:15pm	Jefferson City	18h 55m	2:10pm	537-517 W. Jackson Blvd	No tags

Next departures for Jefferson City to Chicago on November 30
Operated by	Vehicle type	Departure time	Departure location	Trip duration	Arrival time	Arrival location	Recommended
Greyhound Lines, Inc. + FlixBus	Bus	7:15pm	Jefferson City	10h 5m	5:20am	Chicago 95Th & Dan Ryan	CheapestFastest
Greyhound Lines, Inc. + FlixBus	Bus	7:15pm	Jefferson City	10h 30m	5:45am	Downtown Greyhound Station	No tags
	Bus	7:15pm	Jefferson City	18h 55m	2:10pm	537-517 W. Jackson Blvd	No tags

Last refresh of the prices: Yesterday at 10:10 PM CST.

Compare 2 ways to go from Jefferson City to Chicago

We recommend taking the train

Among the sustainable travel choices, the train stands out as a good way to reach Chicago. The journey takes about 8 hours 11 minutes, and with fares starting at just $71, it presents an excellent value for a comfortable ride.

2train per day

8h 11mAverage Duration

532 kmDistance

48kgCO₂ emissions

	Average Price	Average Duration	CO₂ emissions	Actions
Bus	Average Price$81 - $252	Average Duration10h 30m	CO₂ emissions 13kg CO₂e
Train	Average Price$71 - $212	Average Duration8h 11m	CO₂ emissions 48kg CO₂e

Compare bus companies

Greyhound

3.5/587,391 reviews

Staff3.6

Timeliness2.9

Cleanliness3.3

Wifi2.4

Based on 87391 reviews, the company was rated 3.5 stars on Busbud. Travellers were especially satisfied with the ticket access and the temperature but often complained with the WiFi. Greyhound ticket prices on this trip start at $85

US Bus Companies: FlixBus, BlaBlaCar Bus, ALSA, Greyhound, Intercape, Trenitalia, Sindbad

Frequently asked questions about travelling from Jefferson City, MO to Chicago by bus

What is the travel distance from Jefferson City to Chicago?
It's about 531 km (329 miles) from Jefferson City to Chicago.

Find cheapest prices for buses

Price is for a one-way ticket for one passenger and based on past searches.

Best price found

11-21

$216

11-22

$184

Today

$193

11-24

$281

11-25

$274

11-26

$190

11-27

$171

11-28

$255

The cheapest trip from Jefferson City, MO to Chicago was searched and found on Nov 27, 2025 with a price of $171

To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Jefferson City, MO to Chicago, as early as possible.

You can expect to pay from $171 to $281 for a bus ticket from Jefferson City, MO to Chicago based on the last 2 days. You can expect to find the cheapest price for the trip at $171 which is on 2025-11-27.