How much is the bus ticket from Florence to Chicago?

The cheapest bus tickets from Florence to Chicago start from $124. The average price for this route is around $186. Busbud recommends that you book your tickets in advance for a better chance to get the lowest possible price.

How long is the bus ride from Florence to Chicago?

The average bus trip duration from Florence to Chicago is 1d 3h, covering a distance of 672 miles (1084 km). The quickest bus can get you there in 1d and is operated by Greyhound .

Which bus companies service the Florence to Chicago route?

Several major bus companies operate on this route with 12 buses available per day, including services from Greyhound , FlixBus .

What is the earliest and latest departure time for the bus from Florence to Chicago?

The earliest bus departs from Florence to Chicago at 12:05am. And the latest bus departs at 4:30pm.

What are the CO₂ emissions for the bus trip from Florence to Chicago?

A bus trip from Florence to Chicago generates an estimated 27 kg of CO₂, making it a highly eco-friendly travel option and recommended mode of travel by Busbud.

What is the best bus company from Florence to Chicago?

According to Busbud customers, the highest-rated bus company on this route is Greyhound , with an average rating of 3.5 out of 5 stars based on 87435 reviews.

Which bus company has the best Wi-Fi from Florence to Chicago?

Based on reviews on Busbud, the bus company FlixBus has the best Wi-Fi rating with a score of 2.7.

Which bus company has the most timely service from Florence to Chicago?

According to Busbud traveller reviews, the most timely bus company on this route is FlixBus , with a punctuality rating of 3.9 out of 5 stars.

Which bus company has the cleanest buses from Florence to Chicago?

According to Busbud traveller reviews, the bus company with the cleanest buses on this route is FlixBus , with a cleanliness rating of 4.1 out of 5 stars.

Bus Florence to Chicago from $116 | Refundable Tickets

Next bus departures

Next departures for Florence to Chicago on December 21
Operated by	Vehicle type	Departure time	Departure location	Trip duration	Arrival time	Arrival location	Recommended
Greyhound Lines, Inc. + FlixBus	Bus	4:10pm	Bus station	1d	3:55pm	Chicago 95Th & Dan Ryan	Cheapest
	Bus	4:10pm	Bus station	1d	3:15pm	Downtown Greyhound Station	Fastest
Greyhound Lines, Inc. + FlixBus	Bus	4:30pm	Bus station	1d 8h	12:10am	Downtown Greyhound Station	No tags
	Bus	4:30pm	Bus station	1d 16h	8:00am	537-517 W. Jackson Blvd	No tags
Greyhound Lines, Inc. + FlixBus	Bus	4:30pm	Bus station	1d 7h	11:00pm	Chicago 95Th & Dan Ryan	No tags

Next departures for Florence to Chicago on December 22
Operated by	Vehicle type	Departure time	Departure location	Trip duration	Arrival time	Arrival location	Recommended
FlixBus + Greyhound Lines, Inc.	Bus	5:45am	Florence, SC	1d 5h	9:50am	Chicago 95Th & Dan Ryan	Cheapest
	Bus	4:10pm	Bus station	1d	3:15pm	Downtown Greyhound Station	Fastest
Greyhound Lines, Inc. + FlixBus	Bus	11:55am	Bus station	1d	11:30am	Downtown Greyhound Station	No tags
	Bus	11:55am	Bus station	1d 3h	2:10pm	537-517 W. Jackson Blvd	No tags
	Bus	12:05am	Florence, SC	1d 6h	5:40am	Chicago 95Th & Dan Ryan	No tags

Last refresh of the prices: Last Wednesday at 2:44 AM EST.

Compare 2 ways to go from Florence to Chicago

We recommend taking the bus

Among the sustainable travel choices, the bus stands out as the good way to reach Chicago. The journey takes about 1 day, 3 hours 30 minutes and with fares starting at just $124, it presents an excellent value for a comfortable ride.

12bus per day

1d 3hAverage Duration

672 milesDistance

27kgCO₂ emissions

	Average Price	Average Duration	CO₂ emissions	Actions
Bus	Average Price$124 - $587	Average Duration1d 3h	CO₂ emissions 27kg CO₂e
Train	Average Price$286 - $1,904	Average Duration1d 11h	CO₂ emissions 100kg CO₂e

Where are the popular stops in Florence and Chicago?

Stops in Florence

A
Florence Bus Station
619 S Irby St, Florence, SC 29501, USA
Visit page
B
TA Travel Center - Florence
2301 W Lucas St, Florence, SC 29501, USA

Stops in Chicago

A
Downtown Greyhound Station
630 W Harrison St, Chicago, IL 60607, USA
Visit page
B
Chicago O'Hare International Airport
Visit page
C
Polk St & Canal St
500-536 W Polk St, Chicago IL 60607, USA
D
Tornado Bus S Kedzie Ave
2807 S Kedzie Ave, Chicago, IL 60623, USA
E
Cumberland CTA
5800 N Cumberland Ave, Chicago, IL 60631, USA
F
Turimex California Ave
2139 S California Ave, Chicago, IL 60608, USA

Compare bus companies

Greyhound

3.5/587,442 reviews

Staff3.6

Timeliness2.9

Cleanliness3.3

Wifi2.4

Greyhound Lines offers the most comprehensive intercity bus services in the United States. They operate a modern, environmentally friendly fleet that serves more than 2400 destinations and carries nearly 16 million passengers annually. When traveling with them, you can expect free WiFi, onboard entertainment, bathrooms, power outlets and decent legroom. One of the great perks of Greyhound is that they connect big cities and smaller towns in the US, where you usually can't get to by train or plane. If you're looking for safe and affordable transportation, Greyhound is a great choice.

FlixBus

3.5/511,676 reviews

Staff4.1

Timeliness3.9

Cleanliness4.1

Wifi2.7

Flixbus is a European bus operator that offers intercity and bus travel in over 38 countries. Known for their easy-to-spot lime green buses and for offering affordable transportation between cities in Europe and the Americas, Flixbus is a good option for those looking for an affordable, reliable bus company. In their buses, you'll find free WiFi, bathrooms, and power outlets. You can also pay extra to choose your seat and get extra legroom, or even buy a snack or drink onboard directly from the driver. You can reschedule your ticket for a small fee, which varies from $1 to $5, depending on how close you are to the departure date.

US bus companies: FlixBus, BlaBlaCar Bus, Greyhound, ALSA, Intercape, Trenitalia, Big Sky

Frequently asked questions about traveling from Florence, SC, US to Chicago by bus

Please note that schedules, routes, or operator details shown here may be updated or vary at the time of your trip.

How much is the bus ticket from Florence to Chicago?
The cheapest bus tickets from Florence to Chicago start from $124. The average price for this route is around $186. Busbud recommends that you book your tickets in advance for a better chance to get the lowest possible price.
How long is the bus ride from Florence to Chicago?
The average bus trip duration from Florence to Chicago is 1d 3h, covering a distance of 672 miles (1084 km). The quickest bus can get you there in 1d and is operated by Greyhound.
Which bus companies service the Florence to Chicago route?
Several major bus companies operate on this route with 12 buses available per day, including services from Greyhound, FlixBus.
What is the earliest and latest departure time for the bus from Florence to Chicago?
The earliest bus departs from Florence to Chicago at 12:05am. And the latest bus departs at 4:30pm.
What are the CO₂ emissions for the bus trip from Florence to Chicago?
A bus trip from Florence to Chicago generates an estimated 27 kg of CO₂, making it a highly eco-friendly travel option and recommended mode of travel by Busbud.
What is the best bus company from Florence to Chicago?
According to Busbud customers, the highest-rated bus company on this route is Greyhound, with an average rating of 3.5 out of 5 stars based on 87435 reviews.
Which bus company has the best Wi-Fi from Florence to Chicago?
Based on reviews on Busbud, the bus company FlixBus has the best Wi-Fi rating with a score of 2.7.
Which bus company has the most timely service from Florence to Chicago?
According to Busbud traveller reviews, the most timely bus company on this route is FlixBus, with a punctuality rating of 3.9 out of 5 stars.
Which bus company has the cleanest buses from Florence to Chicago?
According to Busbud traveller reviews, the bus company with the cleanest buses on this route is FlixBus, with a cleanliness rating of 4.1 out of 5 stars.

Find cheapest prices for buses

Price is for a one-way ticket for one passenger and based on past searches.

Best price found

12/19

$147

12/20

$203

Today

$141

12/22

$190

12/23

No data

12/24

No data

12/25

No data

12/26

No data

The cheapest trip from Florence, SC, US to Chicago was searched and found on Dec 21, 2025 with a price of $141

To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Florence, SC, US to Chicago, as early as possible.

You can expect to pay from $141 to $414 for a bus ticket from Florence, SC, US to Chicago based on the last 2 days. You can expect to find the cheapest price for the trip at $190 which is on 2025-12-22.