Bus Tickets from Florence, SC, US to Chicago

Previously seen trips

Next departures for Florence to Chicago on November 23
Operated byVehicle typeDeparture timeDeparture locationTrip durationArrival timeArrival locationRecommendedPrice and booking link
FlixBus + Greyhound
Bus
Bus station
Downtown Greyhound StationNo tags
Greyhound + FlixBus
Bus
Bus station
Chicago 95Th & Dan RyanNo tags
GreyhoundBus
Bus station
Downtown Greyhound StationNo tags
GreyhoundBus
Bus station
Chicago 95Th & Dan RyanNo tags
GreyhoundBus
Bus station
537-517 W. Jackson BlvdNo tags

Compare 2 ways to go from Florence to Chicago

We recommend taking the bus

Among the sustainable travel choices, the bus stands out as the good way to reach Chicago. The journey takes about 1 day, 4 hours 55 minutes and with fares starting at just $124, it presents an excellent value for a comfortable ride.

8bus per day
1d 4hAverage Duration
672 milesDistance
27kgCO₂ emissions
Average Price$124 - $354Average Duration1d 4h
27kg CO₂e
Average Price$186 - $1,942Average Duration1d 11h
100kg CO₂e

Frequently asked questions about traveling from Florence, SC, US to Chicago by bus

Find cheapest prices for buses

Price is for a one-way ticket for one passenger and based on past searches.

Best price found
11/21
$230
11/22
No data
Today
No data
11/24
No data
11/25
No data
11/26
No data
11/27
No data
11/28
No data
busbud logoThe cheapest trip from Florence, SC, US to Chicago was searched and found on Nov 21, 2025 with a price of $230

To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Florence, SC, US to Chicago, as early as possible.

What's the cheapest way to go from Florence, SC, US to Chicago?

busbud logoThe bus is the cheapest travel choice for this destination

People from around the world trust Busbud