How far is Des Moines from Milwaukee?

Des Moines and Milwaukee are 308 miles (496 km) apart.

What are the departure and arrival stations when taking the bus from Des Moines to Milwaukee?

Most of the buses traveling from Des Moines to Milwaukee leave from Jefferson/Trailways Depot and arrive at Milwaukee Airport. These are the most popular pick-up and drop-off locations on this route, but you can find others that could fit better into your travel plans.

Bus Des Moines to Milwaukee from $82 | Refundable Tickets

Next bus departures

Next departures for Des Moines to Milwaukee on November 11
Operated by	Vehicle type	Departure time	Departure location	Trip duration	Arrival time	Arrival location	Recommended
Greyhound Lines, Inc. + FlixBus	Bus	5:30am	Des Moines	11h 35m	5:05pm	Milwaukee Bus Station, St. Paul & N6th road.	Cheapest
Greyhound Lines, Inc. + FlixBus	Bus	5:30am	Des Moines	11h 15m	4:45pm	Milwaukee Mitchell MKE Airport	Fastest
	Bus	9:20am	Des Moines	14h 25m	11:45pm	Milwaukee Bus Station, St. Paul & N6th road.	No tags
Greyhound Lines, Inc. + FlixBus	Bus	5:30am	Des Moines	12h 5m	5:35pm	Goerke's Corners Park & Ride (Brookfield)	No tags

Last refresh of the prices: Today at 10:57 AM CST.

Get from Des Moines to Milwaukee

This route is served by bus only

The journey takes about 12 hours 5 minutes and with fares starting at just $61, it presents an excellent value for a comfortable ride.

4bus per day

12h 5mAverage Duration

305 milesDistance

12kgCO₂ emissions

Compare bus companies

Jefferson Lines

4/5759 reviews

Staff4

Timeliness3.8

Cleanliness4

Wifi3.2

Greyhound

3.5/587,366 reviews

Staff3.6

Timeliness2.9

Cleanliness3.3

Wifi2.4

Greyhound Lines offers the most comprehensive intercity bus services in the United States. They operate a modern, environmentally friendly fleet that serves more than 2400 destinations and carries nearly 16 million passengers annually. When traveling with them, you can expect free WiFi, onboard entertainment, bathrooms, power outlets and decent legroom. One of the great perks of Greyhound is that they connect big cities and smaller towns in the US, where you usually can't get to by train or plane. If you're looking for safe and affordable transportation, Greyhound is a great choice.

US bus companies: FlixBus, BlaBlaCar Bus, ALSA, Greyhound, Intercape, Trenitalia, Sindbad

Where are the popular stops in Des Moines and Milwaukee?

Stops in Des Moines

A - Jefferson/Trailways Depot

B - 1514 East Grand Ave

Stops in Milwaukee

A - Milwaukee Airport

B - Intermodal Station

C - S Cesar Chavez

Frequently asked questions about traveling from Des Moines to Milwaukee by bus

How far is Des Moines from Milwaukee?
What are the departure and arrival stations when taking the bus from Des Moines to Milwaukee?

Find cheapest prices for buses

Price is for a one-way ticket for one passenger and based on past searches.

Best price found

11/08

$80

11/09

No data

Today

No data

11/11

$82

11/12

No data

11/13

No data

11/14

No data

11/15

No data

The cheapest trip from Des Moines to Milwaukee was searched and found on Nov 8, 2025 with a price of $80

To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Des Moines to Milwaukee, as early as possible.

You can expect to pay from $80 to $82 for a bus ticket from Des Moines to Milwaukee based on the last 2 days. You can expect to find the cheapest price for the trip at $82 which is on 2025-11-11.