Next departures for Denver to St. Louis on November 25
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DENVER
Gateway Station
CheapestFastest
Next departures for Denver to St. Louis on November 30
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Bus
DENVER
Gateway Station
CheapestFastest
Next departures for Denver to St. Louis on December 1
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DENVER
Gateway Station
CheapestFastest
Last refresh of the prices: Today at 7:46 AM MST.
Compare 2 ways to go from Denver to St. Louis
We recommend taking the bus
Among the sustainable travel choices, the bus stands out as the good way to reach St. Louis. The journey takes about 16 hours 30 minutes and with fares starting at just $86, it presents an excellent value for a comfortable ride.
Greyhound Lines offers the most comprehensive intercity bus services in the United States. They operate a modern, environmentally friendly fleet that serves more than 2400 destinations and carries nearly 16 million passengers annually. When traveling with them, you can expect free WiFi, onboard entertainment, bathrooms, power outlets and decent legroom. One of the great perks of Greyhound is that they connect big cities and smaller towns in the US, where you usually can't get to by train or plane. If you're looking for safe and affordable transportation, Greyhound is a great choice.
Greyhound Denver St. Louis recent customer reviews
Out bound from Denver bus driver said we could not talk, he needed to concentrate. He did not explain emergency exits, told the whole bus personal info of a passenger that was not allowed to board bus.
1 out of 5 stars
Geraldine P.
I experienced a 13hour layover before my bus did manage and did not arrive in St. Louis until 3am as opposed to 1pm. NEVER RIDING AGAIN
Based on 20 reviews, the company was rated 4.2 stars on Busbud. Travelers were especially satisfied with the staff and the timeliness but often complained with the ticket access. Burlington Trailways ticket prices on this trip start at $213
Frequently asked questions about traveling from Denver to St. Louis by bus
What is the travel distance from Denver to St. Louis?
Denver and St. Louis are 794 miles (1281 km) apart.
What are the departure and arrival stations when taking the bus from Denver to St. Louis?
The majority of buses traveling from Denver to St. Louis start their journey at Union Station and wind up at Gateway Station. These are the primary departure and arrival locations on this route, but you could find others that could be a better fit for your travel plans.
What are the best sights and things to do in St. Louis?
Once in St. Louis, you can start exploring the city and discover its surroundings. The top sights and things to do are Powell Symphony Hall, St. Louis Cardinals, Missouri Botanical Garden, Scott Joplin House State Historic Site and Gateway Arch.
Find cheapest prices for buses
Price is for a one-way ticket for one passenger and based on past searches.
Best price found
11/23
$288
11/24
$212
Today
$306
11/26
No data
11/27
No data
11/28
No data
11/29
$126
11/30
$139
The cheapest trip from Denver to St. Louis was searched and found on Nov 29, 2025 with a price of $126
To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Denver to St. Louis, as early as possible.
You can expect to pay from $126 to $306 for a bus ticket from Denver to St. Louis based on the last 2 days. You can expect to find the cheapest price for the trip at $126 which is on 2025-11-29.
What's the cheapest way to go from Denver to St. Louis?
The bus is the cheapest travel choice for this destination
The cheapest trip from Denver to St. Louis was searched and found on Nov 29, 2025 with a price of $126
The bus is the cheapest travel choice for this destination
