Next bus departures
| Operated by | Vehicle type | Departure time | Departure location | Trip duration | Arrival time | Arrival location | Recommended | Price and booking link |
|---|---|---|---|---|---|---|---|---|
 | Bus | Knoxville Bus Station | Gainesville Bus Stop | CheapestFastest | ||||
Greyhound Lines, Inc. + FlixBus | Bus | Knoxville Bus Station | Rosa Parks Station | No tags |
Last refresh of the prices: Today at 3:26 PM EST.
Get from Knoxville to Gainesville
The journey takes about 11 hours 20 minutes, and with fares starting at just R 969, it presents an excellent value for a comfortable ride.
Where are the popular stops in Knoxville and Gainesville?
Stops in Knoxville
- AKnoxville Area Transit Bus Stop, 100 Kirkwood St, Knoxville, TN 37914, USA
Stops in Gainesville
- A700 SE 3rd St, Gainesville, FL 32601
- B3509 SW Williston Rd, Gainesville, FL 32608, USA
- C101 NE 23rd Ave, Gainesville, FL 32609
Compare bus companies
Based on 87397 reviews, the company was rated 3.5 stars on Busbud. Travellers were especially satisfied with the ticket access and the temperature but often complained with the Wi-Fi. Greyhound ticket prices on this trip start at R 969
Frequently asked questions about travelling from Knoxville, TN to Gainesville, FL by bus
How much does a bus ticket from Knoxville to Gainesville cost?
The bus ticket price from Knoxville to Gainesville starts at R 969. The best way to find cheap bus tickets from Knoxville to Gainesville is to book your tickets as early as possible. Prices tend to rise as your travel date approaches, so book in advance to secure the best prices!
How long is the bus ride from Knoxville to Gainesville?
The average travel time between Knoxville and Gainesville is around 11h 20m, although the fastest bus will take about 11h 20m. This is the time it takes to travel the 718 km that separates the two cities.
How many daily bus connections are there between Knoxville and Gainesville?
The number of buses from Knoxville to Gainesville can differ depending on the day of the week. On average, there are 2 on this route. Some buses run direct routes, while others have layovers. Simplify your bus trip from Knoxville to Gainesville by comparing and selecting the bus that fits your travel style and budget on Busbud.
Which bus companies travel from Knoxville to Gainesville?
When taking the bus from Knoxville to Gainesville, you can travel comfortably and safely with Greyhound.
Find cheapest prices for buses
Price is for a one-way ticket for one passenger and based on past searches.
The cheapest trip from Knoxville, TN to Gainesville, FL was searched and found on 27 Nov 2025 with a price of R 2 548To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Knoxville, TN to Gainesville, FL as early as possible.
You can expect to pay from R 2 548 to R 4 322 for a bus ticket from Knoxville, TN to Gainesville, FL based on the last 2 days. You can expect to find the cheapest price for the trip at R 2 548, which is on 2025-11-27.
