Next bus departures
| Operated by | Vehicle type | Departure time | Departure location | Trip duration | Arrival time | Arrival location | Recommended | Price and booking link |
|---|---|---|---|---|---|---|---|---|
 | Bus | Knoxville Bus Station | Gainesville Bus Stop | CheapestFastest | ||||
Greyhound Lines, Inc. + FlixBus | Bus | Knoxville Bus Station | Rosa Parks Station | No tags |
Last refresh of the prices: Today at 15:26 EST.
Get from Knoxville to Gainesville
The journey takes about 11 hours 20 minutes, and with fares starting at just £43, it presents an excellent value for a comfortable ride.
Where are the popular stops in Knoxville and Gainesville?
Stops in Knoxville
- AKnoxville Area Transit Bus Stop, 100 Kirkwood St, Knoxville, TN 37914, USA
Stops in Gainesville
- A700 SE 3rd St, Gainesville, FL 32601
- B3509 SW Williston Rd, Gainesville, FL 32608, USA
- C101 NE 23rd Ave, Gainesville, FL 32609
Compare bus companies
Based on 87397 reviews, the company was rated 3.5 stars on Busbud. Travellers were especially satisfied with the ticket access and the temperature but often complained with the Wi-Fi. Greyhound ticket prices on this trip start at £43
Frequently asked questions about travelling by bus from Knoxville, TN to Gainesville, FL
What's the distance between Knoxville and Gainesville by coach?
The distance between Knoxville and Gainesville by coach is approximately 446 miles (718 km).
What is the best way to go from Knoxville to Gainesville without flying?
You have the option to select the coach for your journey on this route. The coach ensures a pleasant travel experience, granting you the opportunity to appreciate the scenery as you make your way to your final stop. You might also find carpooling options to travel between the two cities.
Find cheapest prices for buses
Price is for a one-way ticket for one passenger and based on past searches.
The cheapest trip from Knoxville, TN to Gainesville, FL was searched and found on 27 Nov 2025 with a price of £113To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Knoxville, TN to Gainesville, FL as early as possible.
You can expect to pay from £113 to £191 for a bus ticket from Knoxville, TN to Gainesville, FL based on the last 2 days. You can expect to find the cheapest price for the trip at £113, which is on 2025-11-27.
