Find coaches from Jacksonville, FL to Florence, SC, US

Next departures

Next departures from Jacksonville to Florence on 3 November
Operated byVehicle typeDeparture timeDeparture locationTrip durationArrival timeArrival locationRecommendedPrice and booking link
FlixBus
    		Jacksonville Bus Station
    		Florence, SCCheapest
    FlixBus
      		Jacksonville Bus Station
      		Bus stationFastest

      Last refresh of the prices: Yesterday at 8:25 AM EST.

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      Compare 2 ways to travel from Jacksonville to Florence

      We recommend taking the bus

      Among the sustainable travel choices, the bus stands out as a good way to reach Florence. The journey takes about 7 hours and with fares starting at just US$48, it presents an excellent value for a comfortable ride.

      2bus per day
      7hAverage duration
      465 kmDistance
      12kgCO₂ emissions
      Bus
      		Average priceUS$48 - US$99Average duration7h
      12kg CO₂e
      Train
      		Average priceUS$52 - US$117Average duration6h 11m
      42kg CO₂e

      Bus Jacksonville, FL to Florence, SC, US: Trip Overview

      Average ticket priceUS$71
      Average bus trip duration7h
      Number of daily buses2
      Earliest bus departure08:25
      Distance465 km
      Latest bus departure18:30

      Jacksonville to Florence Bus

      With Busbud, comparing and booking tickets for a bus from Jacksonville to Florence is a breeze. Browse through an extensive selection of bus fares and bus schedules to find the best deals.

      Bus service from Jacksonville to Florence will be provided by the most trusted bus companies.

      Whether it is cheap bus tickets or more luxurious buses going to Florence from Jacksonville, we help you find what you're looking for based on how much of a budget you have.

      Frequently asked questions on the trip Jacksonville, FL - Florence, SC, US

      1. How much does a bus ticket from Jacksonville to Florence cost?

        The bus ticket price from Jacksonville to Florence starts at US$48. The best way to find cheap bus tickets from Jacksonville to Florence is to book your tickets as early as possible. Prices tend to rise as your travel date approaches, so book in advance to secure the best prices!

      2. How long is the bus ride from Jacksonville to Florence?

        The average travel time between Jacksonville and Florence is around 7h, although the fastest bus will take about 5h 10m. This is the time it takes to travel the 472 km that separates the two cities.

      3. How many daily bus connections are there between Jacksonville and Florence?

        The number of buses from Jacksonville to Florence can differ depending on the day of the week. On average, there are 2 on this route. Some buses run direct routes, while others have layovers. Simplify your bus trip from Jacksonville to Florence by comparing and selecting the bus that fits your travel style and budget on Busbud.

      4. Which bus companies travel from Jacksonville to Florence?

        When taking the bus from Jacksonville to Florence, you can travel comfortably and safely with FlixBus, Greyhound.

      5. What are the departure and arrival stations when taking the bus from Jacksonville to Florence?

        Buses travelling between Jacksonville and Florence leave from Jacksonville Amtrak Station or W Forsyth St and arrive at Florence Bus Station, TA Travel Center - Florence.

      Find cheapest prices for buses

      Price is for a one-way ticket for one passenger and based on past searches.

      Best price found
      01/11
      US$40
      02/11
      No data
      Today
      US$50
      04/11
      No data
      05/11
      No data
      06/11
      US$51
      07/11
      No data
      08/11
      US$43
      busbud logoThe cheapest trip from Jacksonville, FL to Florence, SC, US was searched and found on 01 Nov 2025 with a price of US$40

      To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Jacksonville, FL to Florence, SC, US as early as possible.

      You can expect to pay from US$40 to US$70 for a bus ticket from Jacksonville, FL to Florence, SC, US based on the last 2 days. You can expect to find the cheapest price for the trip at US$43, which is on 2025-11-08.

      About Bus Travel

      Bus Travel Tips

      Meet and talk to locals at the bus stations while travelling from Jacksonville to Florence.There is no better way to get inside travel information while exploring a new city than to go straight to its people.

      Much more than a mere vehicle taking you from Jacksonville to Florence, riding the bus will expose you to some of the most stunning panoramas while enroute to your final bus stop.

      Buses are energy-efficient. Carrying a passenger over 100 kms by coach only takes 0.6-0.9 liters of gas. Compare that to the 2.6 liters required by high-speed train, 6.6 liters by airplane and 7.6 liters by gas-powered car, and it's clear that the bus is a more environmentally-conscious option for your bus transportation from Jacksonville to Florence.

      Create your own real life musical score by curating a personalized bus travel playlist - the perfect accompaniment to your bus ride from Jacksonville to Florence.

      Did you know?

      Did you know some bus companies in Germany offer to their passenger low-costs snacks and regional beer based on their destination? Prosit!

      9.2% of ground transportation in Europe is done by bus versus 7.4% by train.

      The average number of passengers on a coach bus is 32 meaning that a bus could replace a minimum of at least 30 cars!

      What's the cheapest way to go from Jacksonville, FL to Florence, SC, US?

      busbud logoThe bus is the cheapest travel choice for this destination

      Will you be returning to Jacksonville, FL by bus?

      Bus from Florence, SC, US to Jacksonville, FL

      You can also go to Florence, SC, US by train

      Train from Jacksonville, FL to Florence, SC, US

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