Previously seen trips
| Operated by | Vehicle type | Departure time | Departure location | Trip duration | Arrival time | Arrival location | Recommended | Price and booking link |
|---|---|---|---|---|---|---|---|---|
 | Jacksonville Bus Station | Bus station | No tags | |||||
 | Jacksonville Bus Station | Florence, SC | No tags | |||||
| Jacksonville Bus Station | Bus station | No tags | |||||
| Jacksonville Bus Station | Florence, SC | No tags | |||||
| Jacksonville Bus Station | Bus station | No tags |
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Compare 2 ways to go from Jacksonville to Florence
Among the sustainable travel choices, the bus stands out as a good way to reach Florence. The journey takes about 7 hours, and with fares starting at just $68, it presents an excellent value for a comfortable ride.
Bus Jacksonville, FL to Florence, SC, US: Trip Overview
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Jacksonville to Florence Bus
With Busbud, comparing and booking tickets for a bus from Jacksonville to Florence is a breeze. Browse through an extensive selection of bus fares and bus schedules to find the best deals.
Bus service from Jacksonville to Florence will be provided by the most trusted bus companies.
Whether it is cheap bus tickets or more luxurious buses going to Florence from Jacksonville, we help you find what you're looking for based on how much of a budget you have.
Where are the popular stops in Jacksonville and Florence?
Frequently asked questions on the trip Jacksonville, FL - Florence, SC, US
What is the distance between Jacksonville and Florence?
It's about 472 km (293 miles) from Jacksonville to Florence.
What are the departure and arrival locations for buses traveling from Jacksonville to Florence?
Buses traveling this route start their trip at Jacksonville Amtrak Station, in Jacksonville, and end it at Florence Bus Station, in Florence.
Find cheapest prices for buses
Price is for a one-way ticket for one passenger and based on past searches.
The cheapest trip from Jacksonville, FL to Florence, SC, US was searched and found on Nov 1, 2025 with a price of $58To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Jacksonville, FL to Florence, SC, US, as early as possible.
You can expect to pay from $58 to $101 for a bus ticket from Jacksonville, FL to Florence, SC, US based on the last 2 days. You can expect to find the cheapest price for the trip at $62 which is on 2025-11-08.
About Bus Travel
Bus Travel Tips
Meet and talk to locals at the bus stations while travelling from Jacksonville to Florence.There is no better way to get inside travel information while exploring a new city than to go straight to its people.
Much more than a mere vehicle taking you from Jacksonville to Florence, riding the bus will expose you to some of the most stunning panoramas while enroute to your final bus stop.
Buses are energy-efficient. Carrying a passenger over 100 kms by coach only takes 0.6-0.9 liters of gas. Compare that to the 2.6 liters required by high-speed train, 6.6 liters by airplane and 7.6 liters by gas-powered car, and it's clear that the bus is a more environmentally-conscious option for your bus transportation from Jacksonville to Florence.
Create your own real life musical score by curating a personalized bus travel playlist - the perfect accompaniment to your bus ride from Jacksonville to Florence.
Did you know?
Did you know some bus companies in Germany offer to their passenger low-costs snacks and regional beer based on their destination? Prosit!
9.2% of ground transportation in Europe is done by bus versus 7.4% by train.
The average number of passengers on a coach bus is 32 meaning that a bus could replace a minimum of at least 30 cars!
What's the cheapest way to go from Jacksonville, FL to Florence, SC, US?
The bus is the cheapest travel choice for this destinationTop travelled bus routes
Why choose Busbud?
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Popular Buses Connecting Jacksonville
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Popular Buses Connecting Florence
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Buses Going to Florence
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