Next bus departures
| Operated by | Vehicle type | Departure time | Departure location | Trip duration | Arrival time | Arrival location | Recommended | Price and booking link |
|---|---|---|---|---|---|---|---|---|
FlixBus + Greyhound Lines, Inc. | Bus | Downtown Transit Center | Des Moines | Cheapest | ||||
 | Bus | Indianapolis Bus Station | Des Moines | Fastest | ||||
FlixBus + Greyhound Lines, Inc. | Bus | Downtown Transit Center | Des Moines | No tags |
Last refresh of the prices: Last Thursday at 9:44 PM EST.
Get from Indianapolis to Des Moines
The journey takes about 15 hours 45 minutes, and with fares starting at just R 1 272, it presents an excellent value for a comfortable ride.
Where are the popular stops in Indianapolis and Des Moines?
Stops in Des Moines
- A
Jefferson/Trailways Depot
1501 2nd Ave North, Des Moines, IA 50314 - B
1514 East Grand Ave
1514 East Grand Avenue,, Des Moins, IA, 50316
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Frequently asked questions about travelling from Indianapolis to Des Moines by bus
How much does a bus ticket from Indianapolis to Des Moines cost?
The bus ticket price from Indianapolis to Des Moines starts at R 1 272. The best way to find cheap bus tickets from Indianapolis to Des Moines is to book your tickets as early as possible. Prices tend to rise as your travel date approaches, so book in advance to secure the best prices!
How long is the bus ride from Indianapolis to Des Moines?
The average travel time between Indianapolis and Des Moines is around 15h 45m, although the fastest bus will take about 12h 55m. This is the time it takes to travel the 661 km that separates the two cities.
How many daily bus connections are there between Indianapolis and Des Moines?
The number of buses from Indianapolis to Des Moines can differ depending on the day of the week. On average, there are 3 on this route. Some buses run direct routes, while others have layovers. Simplify your bus trip from Indianapolis to Des Moines by comparing and selecting the bus that fits your travel style and budget on Busbud.
Which bus companies travel from Indianapolis to Des Moines?
When taking the bus from Indianapolis to Des Moines, you can travel comfortably and safely with Greyhound, Burlington Trailways, FlixBus.
Find cheapest prices for buses
Price is for a one-way ticket for one passenger and based on past searches.
The cheapest trip from Indianapolis to Des Moines was searched and found on 28 Nov 2025 with a price of R 1 580To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Indianapolis to Des Moines as early as possible.
You can expect to pay from R 1 580 to R 2 645 for a bus ticket from Indianapolis to Des Moines based on the last 2 days. You can expect to find the cheapest price for the trip at R 1 580, which is on 2025-11-28.
