Next bus departures
| Operated by | Vehicle type | Departure time | Departure location | Trip duration | Arrival time | Arrival location | Recommended | Price and booking link |
|---|---|---|---|---|---|---|---|---|
FlixBus + Greyhound Lines, Inc. | Bus | Downtown Transit Center | Des Moines | Cheapest | ||||
 | Bus | Indianapolis Bus Station | Des Moines | Fastest | ||||
| Bus | Indianapolis Bus Station | Des Moines | No tags | ||||
FlixBus + Greyhound Lines, Inc. | Bus | Downtown Transit Center | Des Moines | No tags |
Last refresh of the prices: Yesterday at 05:50 EST.
Get from Indianapolis to Des Moines
The journey takes about 15 hours 45 minutes, and with fares starting at just £56, it presents an excellent value for a comfortable ride.
Where are the popular stops in Indianapolis and Des Moines?
Stops in Des Moines
- A
Jefferson/Trailways Depot
1501 2nd Ave North, Des Moines, IA 50314 - B
1514 East Grand Ave
1514 East Grand Avenue,, Des Moins, IA, 50316
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Frequently asked questions about travelling by bus from Indianapolis to Des Moines
What's the distance between Indianapolis and Des Moines by coach?
The distance between Indianapolis and Des Moines by coach is approximately 410 miles (661 km).
How can I travel from Indianapolis to Des Moines avoiding air travel?
You can choose the coach to travel this route. The coach ensures a pleasant travel experience, granting you the opportunity to appreciate the scenery as you make your way to your final stop. You might also find carpooling options to travel between the two cities.
Find cheapest prices for buses
Price is for a one-way ticket for one passenger and based on past searches.
The cheapest trip from Indianapolis to Des Moines was searched and found on 2 Dec 2025 with a price of £69To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Indianapolis to Des Moines as early as possible.
You can expect to pay from £69 to £201 for a bus ticket from Indianapolis to Des Moines based on the last 2 days. You can expect to find the cheapest price for the trip at £69, which is on 2025-12-02.
