Next bus departures
| Operated by | Vehicle type | Departure time | Departure location | Trip duration | Arrival time | Arrival location | Recommended | Price and booking link |
|---|---|---|---|---|---|---|---|---|
 | Bus | Indianapolis Bus Station | Des Moines | CheapestFastest | ||||
| Bus | Indianapolis Bus Station | Des Moines | No tags | ||||
FlixBus + Greyhound Lines, Inc. | Bus | Downtown Transit Center | Des Moines | No tags | ||||
FlixBus + Greyhound Lines, Inc. | Bus | Downtown Transit Center | Des Moines | No tags |
Last refresh of the prices: Last Thursday at 9:45 PM EST.
Get from Indianapolis to Des Moines
The journey takes about 15 hours 45 minutes, and with fares starting at just $104, it presents an excellent value for a comfortable ride.
Where are the popular stops in Indianapolis and Des Moines?
Stops in Des Moines
- A
Jefferson/Trailways Depot
1501 2nd Ave North, Des Moines, IA 50314 - B
1514 East Grand Ave
1514 East Grand Avenue,, Des Moins, IA, 50316
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Frequently asked questions about travelling from Indianapolis to Des Moines by bus
How far is Indianapolis from Des Moines?
The distance between Indianapolis and Des Moines is around 661 km (410 miles).
What are the departure and arrival locations for buses traveling from Indianapolis to Des Moines?
Buses traveling this route start their trip at Greyhound Amtrak Station, in Indianapolis, and end it at Jefferson/Trailways Depot, in Des Moines.
Find cheapest prices for buses
Price is for a one-way ticket for one passenger and based on past searches.
The cheapest trip from Indianapolis to Des Moines was searched and found on Nov 28, 2025 with a price of $129To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Indianapolis to Des Moines, as early as possible.
You can expect to pay from $129 to $216 for a bus ticket from Indianapolis to Des Moines based on the last 2 days. You can expect to find the cheapest price for the trip at $129 which is on 2025-11-28.
Top travelled bus routes
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Popular bus departures from Indianapolis
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