Bus from Santiago, CL to La Serena, CL: Tickets & Timetables

Next bus departures

Next departures from Santiago to La Serena on 30 November
Operated byVehicle typeDeparture timeDeparture locationTrip durationArrival timeArrival locationRecommendedPrice and booking link
Buses RomaniBus
Terminal de Buses San Borja - San Francisco de Borja
Terminal de Buses La SerenaCheapest
Serena MarBus
    San Borja
    Terminal de Buses La SerenaFastest
    Cikbus ElitéBus
    Terminal de Buses San Borja - San Francisco de Borja
    Terminal de Buses La SerenaNo tags
    Pluss ChileBus
    San Borja
    Terminal de Buses La SerenaNo tags
    ParaviasBus
    San Borja
    Terminal de Buses La SerenaNo tags

    Last refresh of the prices: Yesterday at 19:44 -03.

    Get from Santiago to La Serena

    This route is served by bus only

    The journey takes about 6 hours 20 minutes, and with fares starting at just £7, it presents an excellent value for a comfortable ride.

    81bus per day
    6h 20mAverage duration
    247 milesDistance
    10kgCO₂ emissions

    Frequently asked questions about travelling by bus from Santiago, CL to La Serena, CL

    Please note that timetables, routes, or operator details shown here may be updated or vary at the time of your journey.

    1. How much is the bus ticket from Santiago to La Serena?

      The cheapest coach tickets from Santiago to La Serena start from £7. The average price for this route is around £15. Busbud recommends that you book your tickets in advance for a better chance to get the lowest possible price.

    2. How long is the bus journey from Santiago to La Serena?

      The average bus journey time from Santiago to La Serena is 6h 20m, covering a distance of 247 miles. The fastest bus can take you there in 5h 30m and is operated by Serena Mar.

    3. Which bus companies service the Santiago to La Serena route?

      Several major bus companies operate on this route with 81 buses available per day, including services from Pluss Chile, FlixBus, Cikbus Elité, Buses Andimar, Buses Romani, Pullman San Andres, Buses Paravias, Serena Mar, Buses Evans, Condor Bus, Clikbus.

    4. What is the earliest and latest departure time for the bus from Santiago to La Serena?

      The earliest bus departs from Santiago to La Serena at 06:15. And the latest bus departs at 23:59.

    5. What are the CO₂ emissions for the bus trip from Santiago to La Serena?

      A bus journey from Santiago to La Serena produces an estimated 10 kg of CO₂, making it a highly eco-friendly choice and a mode of travel recommended by Busbud.

    6. Which is the best bus company from Santiago to La Serena?

      According to Busbud customers, the highest-rated bus company on this route is Clikbus, with an average rating of 4.3 out of 5 stars based on 3 reviews.

    7. Which company has the best Wi-Fi from Santiago to La Serena?

      Based on Busbud reviews, the bus company FlixBus has the best Wi-Fi rating with a score of 2.7.

    8. Which bus company offers the most punctual service from Santiago to La Serena?

      According to Busbud traveller reviews, the most punctual bus company on this route is Clikbus, with a punctuality rating of 5.0 out of 5 stars.

    9. Which bus company has the cleanest buses from Santiago to La Serena?

      According to Busbud traveller reviews, the bus company with the cleanest buses on this route is Pluss Chile, with a cleanliness rating of 4.6 out of 5 stars.

    Find cheapest prices for buses

    Price is for a one-way ticket for one passenger and based on past searches.

    Best price found
    27/11
    £7
    28/11
    £9
    Today
    £7
    30/11
    £7
    01/12
    £7
    02/12
    £7
    03/12
    £7
    04/12
    £7
    busbud logoThe cheapest trip from Santiago, CL to La Serena, CL was searched and found on 29 Nov 2025 with a price of £7

    To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Santiago, CL to La Serena, CL as early as possible.

    You can expect to pay from £7 to £31 for a bus ticket from Santiago, CL to La Serena, CL based on the last 2 days. You can expect to find the cheapest price for the trip at £7, which is on 2025-11-30.

    Usually Pluss Chile will charge you higher prices for tickets closer to the departure date. To find the best prices, you should be flexible on your date of travel.

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