Based on 82 reviews, the company was rated 3.9 stars on Busbud. Travellers were especially satisfied with the departure location and the cleanliness but often complained with the WiFi. Pluss Chile ticket prices on this trip start at $13
Based on 11417 reviews, the company was rated 3.5 stars on Busbud. Travellers were especially satisfied with the ticket access and the staff but often complained with the WiFi. FlixBus ticket prices on this trip start at $13
Based on 125 reviews, the company was rated 3.7 stars on Busbud. Travellers were especially satisfied with the staff and the ticket access but often complained with the WiFi. Cikbus Elité ticket prices on this trip start at $13
Cikbus Elité / Ciktur Santiago La Serena recent customer reviews
Timely service, arrived a little early at destination. Comfortable, but the seat my partner had would not stay upright, it would slowly recline.
4 out of 5 stars
Nigel P.
The best company I have ever seen. Really comfortable seats and pillows. I have problems with sleeping in buses but now I had decent rest. I recommend
Based on 54 reviews, the company was rated 4.2 stars on Busbud. Travellers were especially satisfied with the ticket access and the seats but often complained with the WiFi. Buses Andimar ticket prices on this trip start at $20
Andimar Santiago La Serena recent customer reviews
We actually rebooked to Flixbus. We felt very safe two drivers and supported by a third person. Very properly! Nice service!
Based on 52 reviews, the company was rated 3.8 stars on Busbud. Travellers were especially satisfied with the departure location and the ticket access but often complained with the WiFi. Buses Romani ticket prices on this trip start at $13
Based on 13 reviews, the company was rated 3.6 stars on Busbud. Travellers were especially satisfied with the seats and the temperature but often complained with the timeliness. Pullman San Andres ticket prices on this trip start at $21
According to 12 reviews, Buses Paravias received a 2.6-star rating for this journey. Travellers were especially satisfied with the staff and the seats, but some complained about the temperature. Buses Paravias ticket prices on this trip start at $16
Buses Paravias Santiago La Serena recent customer reviews
Bus showed up an hour late without functioning AC. An hour into the trip the bus broke down and we had to wait two hours for a replacement, we were a total of 4 hours late to our destination. Never again.
1 out of 5 stars
Marco André A.
my bus was canceled, there was no information about it, I did not get refund for the ticket
1 out of 5 stars
Stefano S.
The bus really smelt of toilet and the air conditioner was broken. There was a window that the staff were not happy for us to open.
Based on 12 reviews, Serena Mar was rated 4 stars for this trip. Serena Mar ticket prices on this trip start at $21, with the trip lasting on average 375.
Serena Mar Santiago La Serena recent customer reviews
While we were riding, there were an odd series of noises, noises that I presume were the audio of a film, coming from the speakers above the seats. The noises were quite annoying and went on for some time before the attendant came to stop them.
3 out of 5 stars
Matthew O.
It was a bit dirty
2 out of 5 stars
Andre C.
Toilet didn't work fully, but was a comfortable ride. All in all good!
Buses Evans offers 1 daily departures, and you can find tickets starting at $68. The quickest ride takes around 420. Buses Evans offers a cost-effective solution to get you where you need to be.
Based on 19 reviews, Condor Bus was rated 3.6 stars for this trip. Condor Bus ticket prices on this trip start at $22, with the trip lasting on average 418.
Based on 3 reviews, the company was rated 4.3 stars on Busbud. Travellers were especially satisfied with the staff and the timeliness but often complained with the WiFi. Clikbus ticket prices on this trip start at $23
Frequently asked questions about travelling from Santiago, CL to La Serena, CL by bus
How far is Santiago from La Serena?
The distance between Santiago and La Serena is approximately 398 km (247 miles).
What are the departure and arrival locations for buses traveling from Santiago to La Serena?
Buses departing from San Borja in Santiago will take you to Terminal de Buses La Serena in La Serena.
Find cheapest prices for buses
Price is for a one-way ticket for one passenger and based on past searches.
Best price found
11-21
$13
11-22
$13
Today
$31
11-24
$13
11-25
$12
11-26
$12
11-27
$12
11-28
$13
The cheapest trip from Santiago, CL to La Serena, CL was searched and found on Nov 25, 2025 with a price of $12
To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Santiago, CL to La Serena, CL, as early as possible.
You can expect to pay from $12 to $50 for a bus ticket from Santiago, CL to La Serena, CL based on the last 2 days. You can expect to find the cheapest price for the trip at $12 which is on 2025-11-25.
Usually Pluss Chile will charge you higher prices for tickets closer to the departure date. To find the best prices, you should be flexible on your date of travel.
The cheapest trip from Santiago, CL to La Serena, CL was searched and found on Nov 25, 2025 with a price of $12
