Next bus departures
| Operated by | Vehicle type | Departure time | Departure location | Trip duration | Arrival time | Arrival location | Recommended | Price and booking link |
|---|---|---|---|---|---|---|---|---|
 | Bus | Panama City Beach Station | Jacksonville Bus Station | Cheapest | ||||
| Bus | Panama City Beach Station | Jacksonville Bus Station | Fastest |
Last refresh of the prices: Today at 09:21 CST.
Get from Panama City to Jacksonville
The journey takes about 6 hours 45 minutes, and with fares starting at just £37, it presents an excellent value for a comfortable ride.
Where are the popular stops in Panama City and Jacksonville?
Stops in Panama City
- A
Panama City Greyhound Bus Station
917 Harrison Ave, Panama City, FL 32401
Stops in Jacksonville
- A3570 Clifford Ln, Jacksonville, FL 32209, USA
- B
W Forsyth St
1111 W Forsyth St, Jacksonville, FL 32204, USA - C
Kings Avenue Station
1003 Kings Avenue, Jacksonville, FL 32207 - D
JRTC Greyhound Bus Station
111 W. Forsyth St, Jacksonville, FL 32202, USA
Compare bus companies
Based on 87407 reviews, the company was rated 3.5 stars on Busbud. Travellers were especially satisfied with the ticket access and the temperature but often complained with the Wi-Fi. Greyhound ticket prices on this trip start at £37
Frequently asked questions about travelling by bus from Panama City, US to Jacksonville, FL
Please note that timetables, routes, or operator details shown here may be updated or vary at the time of your journey.
How much is the bus ticket from Panama City to Jacksonville?
The cheapest coach tickets from Panama City to Jacksonville start from £37. The average price for this route is around £48. Busbud recommends that you book your tickets in advance for a better chance to get the lowest possible price.
How long is the bus journey from Panama City to Jacksonville?
The average bus journey time from Panama City to Jacksonville is 6h 45m, covering a distance of 245 miles. The fastest bus can take you there in 6h 45m and is operated by Greyhound.
Which bus companies service the Panama City to Jacksonville route?
Several major bus companies operate on this route with 1 buses available per day.
What is the earliest and latest departure time for the bus from Panama City to Jacksonville?
The earliest bus departs from Panama City to Jacksonville at 07:25. And the latest bus departs at 12:50.
What are the CO₂ emissions for the bus trip from Panama City to Jacksonville?
A bus journey from Panama City to Jacksonville produces an estimated 10 kg of CO₂, making it a highly eco-friendly choice and a mode of travel recommended by Busbud.
Find cheapest prices for buses
Price is for a one-way ticket for one passenger and based on past searches.
The cheapest trip from Panama City, US to Jacksonville, FL was searched and found on 28 Nov 2025 with a price of £52To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Panama City, US to Jacksonville, FL as early as possible.
You can expect to pay from £52 to £92 for a bus ticket from Panama City, US to Jacksonville, FL based on the last 2 days. You can expect to find the cheapest price for the trip at £55, which is on 2025-11-29.
