How much does a cheap train ticket from Greenville to Chicago cost?

The average train ticket price from Greenville to Chicago is $406. The best way to find cheap train tickets from Greenville to Chicago is to book your tickets as early as possible. Prices tend to rise as your travel date approaches, so book in advance to secure the best prices!

How long is the trip from Greenville to Chicago?

A train trip between Greenville and Chicago is around 1d 7h, although the fastest train will take about 1d 7h. This is the time it takes to travel the 904 km that separates the two cities.

How many daily trains are there between Greenville and Chicago?

The number of trains from Greenville to Chicago can differ depending on the day of the week. On average, there is 1. Some trains are direct while others have layovers. Simplify your train trip from Greenville to Chicago by comparing and selecting the train that fits your travel style and budget on Busbud.

Which train companies travel from Greenville to Chicago?

When taking the train from Greenville to Chicago, you can travel comfortably and safely with Amtrak.

Train Greenville to Chicago from $274 | Refundable Tickets

Next train departures

Next departures for Greenville to Chicago on November 24
Operated by	Vehicle type	Departure time	Departure location	Trip duration	Arrival time	Arrival location	Recommended	Price and booking link
	Train	2:23am	Greenville Station	1d 7h	8:45am	Chicago (Union Station), IL	CheapestFastest

Next departures for Greenville to Chicago on November 25
Operated by	Vehicle type	Departure time	Departure location	Trip duration	Arrival time	Arrival location	Recommended	Price and booking link
	Train	2:23am	Greenville Station	1d 7h	8:45am	Chicago (Union Station), IL	CheapestFastest
	Train	2:23am	Greenville Station	1d 7h	8:45am	Chicago (Union Station), IL	No tags

Next departures for Greenville to Chicago on November 26
Operated by	Vehicle type	Departure time	Departure location	Trip duration	Arrival time	Arrival location	Recommended	Price and booking link
	Train	2:23am	Greenville Station	1d 8h	10:00am	Chicago (Union Station), IL	CheapestFastest
	Train	2:23am	Greenville Station	1d 8h	10:00am	Chicago (Union Station), IL	No tags

Next departures for Greenville to Chicago on November 28
Operated by	Vehicle type	Departure time	Departure location	Trip duration	Arrival time	Arrival location	Recommended	Price and booking link
	Train	2:23am	Greenville Station	1d 7h	8:45am	Chicago (Union Station), IL	CheapestFastest
	Train	2:23am	Greenville Station	1d 7h	8:45am	Chicago (Union Station), IL	No tags

Last refresh of the prices: Yesterday at 11:50 PM EST.

Compare 2 ways to go from Greenville to Chicago

We recommend taking the bus

Among the sustainable travel choices, the bus stands out as a good way to reach Chicago. The journey takes about 21 hours 30 minutes, and with fares starting at just $118, it presents an excellent value for a comfortable ride.

14bus per day

21h 30mAverage Duration

911 kmDistance

23kgCO₂ emissions

	Average Price	Average Duration	CO₂ emissions	Actions
Bus	Average Price$118 - $465	Average Duration21h 30m	CO₂ emissions 23kg CO₂e
Train	Average Price$285 - $2,234	Average Duration1d 7h	CO₂ emissions 82kg CO₂e

Train companies

Amtrak

4/55,601 reviews

Staff4.7

Timeliness3.8

Cleanliness4.6

Wifi3.6

Based on 5601 reviews, the company was rated 4.1 stars on Busbud. Travellers were especially satisfied with the seats and the ticket access but often complained with the WiFi. Amtrak ticket prices on this trip start at $285

US train and bus companies:Amtrak, Trenitalia, Renfe, VIA Rail Canada, Amtrak Acela, NS Nederlandse Spoorwegen, Iryo

Frequently asked questions about travelling from Greenville, SC to Chicago by train

How much does a cheap train ticket from Greenville to Chicago cost?
The average train ticket price from Greenville to Chicago is $406. The best way to find cheap train tickets from Greenville to Chicago is to book your tickets as early as possible. Prices tend to rise as your travel date approaches, so book in advance to secure the best prices!
How long is the trip from Greenville to Chicago?
A train trip between Greenville and Chicago is around 1d 7h, although the fastest train will take about 1d 7h. This is the time it takes to travel the 904 km that separates the two cities.
How many daily trains are there between Greenville and Chicago?
The number of trains from Greenville to Chicago can differ depending on the day of the week. On average, there is 1. Some trains are direct while others have layovers. Simplify your train trip from Greenville to Chicago by comparing and selecting the train that fits your travel style and budget on Busbud.
Which train companies travel from Greenville to Chicago?
When taking the train from Greenville to Chicago, you can travel comfortably and safely with Amtrak.

Find cheapest prices for trains

Price is for a one-way ticket for one passenger and based on past searches.

Best price found

11-21

$474

11-22

$2,157

Today

$625

11-24

$2,839

11-25

$742

11-26

$334

11-27

No data

11-28

$742

The cheapest trip from Greenville, SC to Chicago was searched and found on Nov 26, 2025 with a price of $334

To save money and be sure you have the best seat, it's a good idea to buy your train tickets from Greenville, SC to Chicago, as early as possible.

You can expect to pay from $334 to $2,839 for a train ticket from Greenville, SC to Chicago based on the last 2 days. You can expect to find the cheapest price for the trip at $334 which is on 2025-11-26.