How much is the train ticket from Greenville to Chicago?

The cheapest train tickets from Greenville to Chicago start from $177. The average price for this train route is around $306. Busbud recommends that you book your tickets in advance for a better chance to get the lowest possible price.

How long is the train journey from Greenville to Chicago?

The average train ride duration from Greenville to Chicago is 1d 7h, covering a distance of 561 miles (904 km). The quickest train can get you there in 1d 7h and is operated by Amtrak .

Which train operators service the Greenville to Chicago route?

Several major train operators operate on this route with 1 trains available per day.

What is the earliest and latest departure time for the train from Greenville to Chicago?

The earliest train departs from Greenville to Chicago at 2:23am. And the latest train departs at 2:23am.

Train Greenville to Chicago from $189 | Refundable Tickets

Previously seen trips

Next departures for Greenville to Chicago on November 30
Vehicle type	Departure time	Departure location	Trip duration	Arrival time	Arrival location	Recommended
Train	2:23am	Greenville Station	1d 8h	10:00am	Chicago (Union Station), IL	No tags
Train	2:23am	Greenville Station	1d 7h	8:45am	Chicago (Union Station), IL	No tags
Train	2:23am	Greenville Station	1d 8h	10:00am	Chicago (Union Station), IL	No tags
Train	2:23am	Greenville Station	1d 7h	8:45am	Chicago (Union Station), IL	No tags
Train	2:23am	Greenville Station	1d 8h	10:00am	Chicago (Union Station), IL	No tags

Compare 2 ways to go from Greenville to Chicago

We recommend taking the bus

Among the sustainable travel choices, the bus stands out as the good way to reach Chicago. The journey takes about 21 hours 30 minutes and with fares starting at just $82, it presents an excellent value for a comfortable ride.

14bus per day

21h 30mAverage Duration

565 milesDistance

23kgCO₂ emissions

	Average Price	Average Duration	CO₂ emissions	Actions
Bus	Average Price$82 - $410	Average Duration21h 30m	CO₂ emissions 23kg CO₂e
Train	Average Price$177 - $2,034	Average Duration1d 7h	CO₂ emissions 82kg CO₂e

Train Companies

Amtrak

4/55,615 reviews

Staff4.7

Timeliness3.8

Cleanliness4.6

Wifi3.6

Based on 5615 reviews, the company was rated 4.1 stars on Busbud. Travelers were especially satisfied with the seats and the ticket access but often complained with the wifi. Amtrak ticket prices on this trip start at $177

Train and bus companies in US:Amtrak, Trenitalia, Renfe, VIA Rail Canada, Amtrak Acela, NS Nederlandse Spoorwegen, Iryo

Frequently asked questions about traveling from Greenville, SC to Chicago by train

Please note that schedules, routes, or operator details shown here may be updated or vary at the time of your trip.

How much is the train ticket from Greenville to Chicago?
The cheapest train tickets from Greenville to Chicago start from $177. The average price for this train route is around $306. Busbud recommends that you book your tickets in advance for a better chance to get the lowest possible price.
How long is the train journey from Greenville to Chicago?
The average train ride duration from Greenville to Chicago is 1d 7h, covering a distance of 561 miles (904 km). The quickest train can get you there in 1d 7h and is operated by Amtrak.
Which train operators service the Greenville to Chicago route?
Several major train operators operate on this route with 1 trains available per day.
What is the earliest and latest departure time for the train from Greenville to Chicago?
The earliest train departs from Greenville to Chicago at 2:23am. And the latest train departs at 2:23am.

Find cheapest prices for trains

Price is for a one-way ticket for one passenger and based on past searches.

Best price found

11/28

$403

11/29

No data

Today

$1,388

12/01

No data

12/02

No data

12/03

No data

12/04

No data

12/05

$189

The cheapest trip from Greenville, SC to Chicago was searched and found on Dec 5, 2025 with a price of $189

To save money and be sure you have the best seat, it's a good idea to buy your train tickets from Greenville, SC to Chicago, as early as possible.

You can expect to pay from $189 to $2,055 for a train ticket from Greenville, SC to Chicago based on the last 2 days. You can expect to find the cheapest price for the trip at $189 which is on 2025-12-05.