Previously seen trips
| Operated by | Vehicle type | Departure time | Departure location | Trip duration | Arrival time | Arrival location | Recommended | Price and booking link |
|---|---|---|---|---|---|---|---|---|
 | Train | Depew Station | Gateway Station | No tags | ||||
| Train | Depew Station | Gateway Station | No tags | ||||
| Train | Depew Station | Gateway Station | No tags | ||||
| Train | Depew Station | Gateway Station | No tags | ||||
| Train | Depew Station | Gateway Station | No tags |
Compare 2 ways to go from Buffalo to St. Louis
Among the sustainable travel choices, the train stands out as a good way to reach St. Louis. The journey takes about 1 day, 30 minutes, and with fares starting at just $242, it presents an excellent value for a comfortable ride.
Where are the popular train stations and stops in Buffalo, NY and St. Louis?
Train companies
Based on 5683 reviews, the company was rated 4.1 stars on Busbud. Travellers were especially satisfied with the seats and the ticket access but often complained with the WiFi. Amtrak ticket prices on this trip start at $242
Frequently asked questions about travelling from Buffalo, NY to St. Louis by train
Please note that schedules, routes, or operator details shown here may be updated or vary at the time of your trip.
How much is the train ticket from Buffalo to St. Louis?
The cheapest train tickets from Buffalo to St. Louis start at $242. The average price for this train route is around $412. Busbud recommends booking your tickets in advance to increase your chances of getting the lowest possible price.
How long is the train ride from Buffalo to St. Louis?
The average train trip from Buffalo to St. Louis takes 1d and covers 1077 km. The quickest train gets you there in 19h 28m and is operated by Amtrak.
Which train operators serve the Buffalo to St. Louis route?
Several major train operators serve this route, with 1 trains available per day.
What are the earliest and latest departure times for the train from Buffalo to St. Louis?
The earliest train from Buffalo to St. Louis departs at 12:39am. The latest train departs at 12:39am.
Find cheapest prices for trains
Price is for a one-way ticket for one passenger and based on past searches.
The cheapest trip from Buffalo, NY to St. Louis was searched and found on Dec 28, 2025 with a price of $396To save money and be sure you have the best seat, it's a good idea to buy your train tickets from Buffalo, NY to St. Louis, as early as possible.
You can expect to pay from $396 to $1,257 for a train ticket from Buffalo, NY to St. Louis based on the last 2 days. You can expect to find the cheapest price for the trip at $396 which is on 2025-12-28.
