Previously seen trips
| Operated by | Vehicle type | Departure time | Departure location | Trip duration | Arrival time | Arrival location | Recommended | Price and booking link |
|---|---|---|---|---|---|---|---|---|
 | Bus | Tampa Bus Station | Lake City Bus Station | No tags | ||||
Greyhound + FlixBus | Bus | Tampa Bus Station | Lake City Bus Station | No tags | ||||
| Bus | Tampa Bus Station | Lake City Bus Station | No tags | ||||
FlixBus + Greyhound | Bus | University of South Florida | Lake City Bus Station | No tags | ||||
Greyhound + FlixBus | Bus | Tampa Bus Station | Lake City Bus Station | No tags |
Get from Tampa to Lake City
The journey takes about 10 hours 25 minutes, and with fares starting at just $44, it presents an excellent value for a comfortable ride.
Where are the popular stops in Tampa and Lake City?
Stops in Tampa
- A
Tampa 13th Avenue Bus Stop (McDonald's)
2101 E 13th Ave (McDonald's), Tampa, FL 33605 - B
Tampa USF, FL
3801 USF Holly Drive, Tampa., FL 33620, USA - C
Greyhound Station
610 E Polk St, Tampa, FL 33602, USA - D
E Sligh Ave
11555 E Sligh Ave, Seffner, FL 33584, USA - E
N Marion St & E Laurel St
551 E Laurel St, Tampa, FL 33602, USA - F
Port of Tampa
200-298 FL-60, Tampa, FL 33602, USA
Stops in Lake City
- A2470 W US HWY 90, Lake City, FL 32025, USA
- B
Lake City Greyhound Bus Station
251 S MARION AVE , 32055, Florida
Compare bus companies
Frequently asked questions about travelling from Tampa to Lake City by bus
What is the travel distance from Tampa to Lake City?
It's about 250 km (155 miles) from Tampa to Lake City.
What are the departure and arrival locations for buses traveling from Tampa to Lake City?
Buses traveling this route start their trip at Tampa 13th Avenue Bus Stop (McDonald's), in Tampa, and end it at Lake City Bus Stop, in Lake City.
Find cheapest prices for buses
Price is for a one-way ticket for one passenger and based on past searches.
The cheapest trip from Tampa to Lake City was searched and found on Nov 24, 2025 with a price of $47To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Tampa to Lake City, as early as possible.
You can expect to pay from $47 to $99 for a bus ticket from Tampa to Lake City based on the last 2 days. You can expect to find the cheapest price for the trip at $73 which is on 2025-11-25.
