How far is Orlando from Florence?

It's about 653 km (405 miles) from Orlando to Florence.

What are the departure and arrival locations for buses traveling from Orlando to Florence?

Buses departing from Orlando Bus Station in Orlando will take you to Florence Bus Station in Florence.

Bus Orlando to Florence from $83 | Refundable Tickets

Next bus departures

Next departures for Orlando to Florence on November 24
Vehicle type	Departure time	Departure location	Trip duration	Arrival time	Arrival location	Recommended
Bus	4:00am	Orlando Bus Station	9h 35m	1:35pm	Bus station	Cheapest
Bus	3:40pm	Orlando Bus Station	8h 25m	12:05am	Florence, SC	Fastest
Bus	4:45am	Orlando Bus Station	8h 50m	1:35pm	Bus station	No tags
Bus	12:45pm	The Florida Mall	11h 20m	12:05am	Florence, SC	No tags

Next departures for Orlando to Florence on November 25
Vehicle type	Departure time	Departure location	Trip duration	Arrival time	Arrival location	Recommended
Bus	4:00am	Orlando Bus Station	9h 35m	1:35pm	Bus station	Cheapest
Bus	3:40pm	Orlando Bus Station	8h 25m	12:05am	Florence, SC	Fastest
Bus	4:45am	Orlando Bus Station	8h 50m	1:35pm	Bus station	No tags
Bus	12:45pm	The Florida Mall	11h 20m	12:05am	Florence, SC	No tags

Last refresh of the prices: Today at 2:37 PM EST.

Compare 2 ways to go from Orlando to Florence

We recommend taking the bus

Among the sustainable travel choices, the bus stands out as a good way to reach Florence. The journey takes about 9 hours 35 minutes, and with fares starting at just $83, it presents an excellent value for a comfortable ride.

3bus per day

9h 35mAverage Duration

647 kmDistance

16kgCO₂ emissions

	Average Price	Average Duration	CO₂ emissions	Actions
Bus	Average Price$83 - $288	Average Duration9h 35m	CO₂ emissions 16kg CO₂e
Train	Average Price$92 - $209	Average Duration9h 46m	CO₂ emissions 59kg CO₂e

Where are the popular stops in Orlando and Florence?

Stops in Orlando

A
Orlando Bus Station
555 N John Young Pkwy, Orlando, FL 32805
Visit page
B
Orlando RedCoach Station
RedCoach Station, 1777 McCoy Road, Orlando, FL 32809
Visit page
C
Jet Set Express Terminal
Jet Set Express Terminal, 3718 LB Mcleod Rd., 32805 Orlando, FL,, United States
Visit page
D
Disney World
Disney's All-Star Sports Resort, 1701 West Buena Vista Dr., Orlando, FL 32830
E
International Dr SuperTours Terminal
5419 International Dr, Orlando, FL 32819, USA
F
Seaworld Hotels
10100 International Drive , Orlando, 32821

Stops in Florence

A
Florence Bus Station
619 S Irby St, Florence, SC 29501, USA
Visit page
B
TA Travel Center - Florence
2301 W Lucas St, Florence, SC 29501, USA

Compare bus companies

FlixBus

3.5/511,414 reviews

Staff4.2

Timeliness3.9

Cleanliness4.1

Wifi2.7

Greyhound

3.5/587,392 reviews

Staff3.6

Timeliness2.9

Cleanliness3.3

Wifi2.4

US Bus Companies: FlixBus, BlaBlaCar Bus, ALSA, Greyhound, Intercape, Trenitalia, Sindbad

Frequently asked questions about travelling from Orlando to Florence, SC, US by bus

How far is Orlando from Florence?
It's about 653 km (405 miles) from Orlando to Florence.
What are the departure and arrival locations for buses traveling from Orlando to Florence?
Buses departing from Orlando Bus Station in Orlando will take you to Florence Bus Station in Florence.

Find cheapest prices for buses

Price is for a one-way ticket for one passenger and based on past searches.

Best price found

11-21

$161

11-22

$171

Today

$171

11-24

$142

11-25

$138

11-26

$126

11-27

$115

11-28

$115

The cheapest trip from Orlando to Florence, SC, US was searched and found on Nov 27, 2025 with a price of $115

To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Orlando to Florence, SC, US, as early as possible.

You can expect to pay from $115 to $249 for a bus ticket from Orlando to Florence, SC, US based on the last 2 days. You can expect to find the cheapest price for the trip at $115 which is on 2025-11-27.