Next bus departures
| Operated by | Vehicle type | Departure time | Departure location | Trip duration | Arrival time | Arrival location | Recommended | Price and booking link |
|---|---|---|---|---|---|---|---|---|
 | Bus | 95 Canal St | 2301 W Lucas St. | CheapestFastest | ||||
| Bus | 103 Canal St | 2301 W Lucas St. | No tags | ||||
 | Bus | New York Port Authority | Bus station | No tags | ||||
Greyhound Lines, Inc. + FlixBus | Bus | New York Port Authority | Florence, SC | No tags | ||||
 | Bus | NYC Midtown (31st St & 8th Ave) | Florence, SC | No tags |
Last refresh of the prices: Yesterday at 10:03 PM EST.
Compare 2 ways to go from New York City to Florence
Among the sustainable travel choices, the train stands out as a good way to reach Florence. The journey takes about 11 hours 53 minutes, and with fares starting at just $144, it presents an excellent value for a comfortable ride.
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Where are the popular stops in New York City and Florence?
Stops in New York City
- A4211 Broadway, New York, NY 10033, USA
- B40-42, 625 8th Ave, New York, NY 10018, USA
- C
Chinatown
122 Allen St, New York, NY 10002-3004 - D
11th Ave (between W35th and W36th Street)
428-436 11th Ave, Stop across from Javits Convention Center, New York, NY 10018, USA - E127 E Broadway, New York, NY 10002, USA
- F
34th St & 9th Ave
367 W 34th St, New York, NY 10001, USA
Stops in Florence
- A619 S Irby St, Florence, SC 29501, USA
- B
TA Travel Center - Florence
2301 W Lucas St, Florence, SC 29501, USA
Frequently asked questions about travelling from New York City to Florence, SC, US by bus
What is the travel distance from New York City to Florence?
It's about 879 km (545 miles) from New York City to Florence.
What are the departure and arrival locations for buses traveling from New York City to Florence?
Buses traveling this route start their trip at GW Bridge, in New York City, and end it at Florence Bus Station, in Florence.
Find cheapest prices for buses
Price is for a one-way ticket for one passenger and based on past searches.
The cheapest trip from New York City to Florence, SC, US was searched and found on Nov 22, 2025 with a price of $163To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from New York City to Florence, SC, US, as early as possible.
You can expect to pay from $163 to $427 for a bus ticket from New York City to Florence, SC, US based on the last 2 days. You can expect to find the cheapest price for the trip at $163 which is on 2025-11-22.
Usually Greyhound, FlixBus will charge you higher prices for tickets closer to the departure date. To find the best prices, you should be flexible on your date of travel.
What's the cheapest way to go from New York City to Florence, SC, US?
The bus is the cheapest travel choice for this destinationTop travelled bus routes
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Popular bus departures from New York City
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