Next bus departures
| Operated by | Vehicle type | Departure time | Departure location | Trip duration | Arrival time | Arrival location | Recommended | Price and booking link |
|---|---|---|---|---|---|---|---|---|
FlixBus + Greyhound Lines, Inc. | Bus | Florence, SC | Schuylkill & Walnut | Cheapest | ||||
 | Bus | Florence, SC | Philadelphia, 199 Spring Garden St | Fastest | ||||
Greyhound Lines, Inc. + FlixBus | Bus | Bus station | 199 Spring Garden St. | No tags | ||||
 | Bus | Bus station | Camden (Walter Rand Transportation Center) | No tags | ||||
| Bus | Florence, SC | Cherry Hill Mall | No tags |
Last refresh of the prices: Yesterday at 1:47 PM EST.
Compare 2 ways to go from Florence to Philadelphia
Among the sustainable travel choices, the train stands out as a good way to reach Philadelphia. The journey takes about 10 hours 57 minutes, and with fares starting at just $131, it presents an excellent value for a comfortable ride.
Compare bus companies
Where are the popular stops in Florence and Philadelphia?
Stops in Florence
- A619 S Irby St, Florence, SC 29501, USA
- B
TA Travel Center - Florence
2301 W Lucas St, Florence, SC 29501, USA
Stops in Philadelphia
- BOff of Race Street between 5th Street and, N 6th St, Philadelphia, PA 19106, USA
- C
#2842 St.Vincent St
15th St Trolley Station, Philadelphia, PA 19102, USA - D
Bus Station
1001 Filbert St, Philadelphia, PA 19107, USA - E
Island Av & Suffolk Av MBFS
3000 Island Ave, Philadelphia, PA 19153, USA - F
NRG SEPTA Station
3701 Broad St, Philadelphia, PA 19148, USA
Frequently asked questions about travelling from Florence, SC, US to Philadelphia, PA by bus
What is the distance between Florence and Philadelphia?
The distance between Florence and Philadelphia is around 753 km (467 miles).
What are the departure and arrival locations for buses traveling from Florence to Philadelphia?
Buses traveling this route start their trip at Florence Bus Station, in Florence, and end it at Philadelphia Airport, in Philadelphia.
Find cheapest prices for buses
Price is for a one-way ticket for one passenger and based on past searches.
The cheapest trip from Florence, SC, US to Philadelphia, PA was searched and found on Nov 19, 2025 with a price of $109To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Florence, SC, US to Philadelphia, PA, as early as possible.
You can expect to pay from $109 to $195 for a bus ticket from Florence, SC, US to Philadelphia, PA based on the last 2 days. You can expect to find the cheapest price for the trip at $135 which is on 2025-11-22.
Usually FlixBus will charge you higher prices for tickets closer to the departure date. To find the best prices, you should be flexible on your date of travel.
What's the cheapest way to go from Florence, SC, US to Philadelphia, PA?
The bus is the cheapest travel choice for this destination
