Next departures
| Operated by | Vehicle type | Departure time | Departure location | Trip duration | Arrival time | Arrival location | Recommended | Price and booking link |
|---|---|---|---|---|---|---|---|---|
 | MFR Airport | Mission St & Fremont St | CheapestFastest | |||||
| MFR Airport | Mission St & Fremont St | No tags | |||||
| Front Street Station | Mission St & Fremont St | No tags | |||||
| Front Street Station | Mission St & Fremont St | No tags |
Last refresh of the prices: Yesterday at 4:33 PM PST.
Get from Medford to San Francisco
The journey takes about 10 hours, and with fares starting at just $152, it presents an excellent value for a comfortable ride.
Where are the popular stops in Medford and San Francisco?
Stops in Medford
- A220 S Front St, Medford, OR 97501
Stops in San Francisco
- A
Hyde/Beach (Fisherman's Wharf)
700 Beach Street, San Francisco, CA 94109, USA - B
Powell Station
25 Cyril Magnin St , San Francisco, CA 94102-2812 - C
Union Square Hilton
255 Mason St,, San Francisco, CA 94102-2114 - D
San Francisco Greyhound Station
200 Folsom St, San Francisco, CA 94105 - E
444 Townsend St.
444 Townsend St, San Francisco, CA 94107, USA
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Frequently asked questions about travelling from Medford, OR to San Francisco, US by bus
Please note that schedules, routes, or operator details shown here may be updated or vary at the time of your trip.
How much is the bus ticket from Medford to San Francisco?
The cheapest bus tickets from Medford to San Francisco start from $152. The average price for this route is around $152. Busbud recommends that you book your tickets in advance for a better chance to get the lowest possible price.
How long is the bus ride from Medford to San Francisco?
The average bus travel time from Medford to San Francisco is 10h, covering a distance of 511 km. The quickest bus can get you there in 10h and is operated by Greyhound.
Which bus companies service the Medford to San Francisco route?
What are the earliest and latest departure times for the bus from Medford to San Francisco?
The earliest bus departs from Medford to San Francisco at 8:05am. And the latest bus departs at 8:05am.
What are the CO₂ emissions for the bus trip from Medford to San Francisco?
A bus trip from Medford to San Francisco generates an estimated 13 kg of CO₂, making it a highly eco-friendly travel option and a mode of travel recommended by Busbud.
What is the best bus company from Medford to San Francisco?
According to Busbud customers, the highest-rated bus company on this route is Amtrak, with an average rating of 4.1 out of 5 stars based on 5597 reviews.
Which bus company has the best Wi-Fi from Medford to San Francisco?
Based on Busbud reviews, the bus company Amtrak has the highest Wi-Fi rating with a score of 3.6.
Which bus company has the best on-time performance from Medford to San Francisco?
According to Busbud traveller reviews, the most punctual bus company on this route is Amtrak, with a punctuality rating of 3.8 out of 5 stars.
Which bus company has the cleanest buses from Medford to San Francisco?
According to Busbud traveller reviews, the bus company with the cleanest buses on this route is Amtrak, with a cleanliness rating of 4.5 out of 5 stars.
Find cheapest prices for buses
Price is for a one-way ticket for one passenger and based on past searches.
The cheapest trip from Medford, OR to San Francisco, US was searched and found on Dec 2, 2025 with a price of $151To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Medford, OR to San Francisco, US, as early as possible.
You can expect to pay from $151 to $683 for a bus ticket from Medford, OR to San Francisco, US based on the last 2 days. You can expect to find the cheapest price for the trip at $151 which is on 2025-12-02.
