What is the travel distance from Medford to San Francisco?

The distance between the two cities is 313 miles (504 km).

What are the departure and arrival stations when taking the bus from Medford to San Francisco?

The majority of buses traveling from Medford to San Francisco start their journey at Front Street Station and wind up at Hyde/Beach (Fisherman's Wharf). These are the main departure and arrival locations on this route, but you can find others that could fit better into your travel plans.

What are the best sights and things to do in San Francisco?

Once in San Francisco, you can start exploring the city and discover its surroundings. The top sights and things to do are Legion of Honor, San Francisco Cable Cars, Alcatraz, Chinatown and Ocean Beach.

Bus Medford to San Francisco from $90 | Refundable Tickets

Next departures

Next departures for Medford to San Francisco on November 27
Departure time	Departure location	Trip duration	Arrival time	Arrival location	Recommended
5:50pm	MFR Airport	15h 30m	9:20am	Mission St & Fremont St	CheapestFastest
5:50pm	MFR Airport	15h 30m	9:20am	Mission St & Fremont St	No tags
4:40pm	Front Street Station	16h 40m	9:20am	Mission St & Fremont St	No tags
4:40pm	Front Street Station	16h 40m	9:20am	Mission St & Fremont St	No tags

Last refresh of the prices: Yesterday at 11:17 PM PST.

Get from Medford to San Francisco

This route is served by bus only

The journey takes about 10 hours and with fares starting at just $106, it presents an excellent value for a comfortable ride.

2bus per day

10hAverage Duration

317 milesDistance

13kgCO₂ emissions

Where are the popular stops in Medford and San Francisco?

Stops in Medford

A
Front Street Station
220 S Front St, Medford, OR 97501
Visit page
B
Medford Airport
Visit page

Stops in San Francisco

A
Hyde/Beach (Fisherman's Wharf)
700 Beach Street, San Francisco, CA 94109, USA
Visit page
B
Powell Station
25 Cyril Magnin St , San Francisco, CA 94102-2812
C
Union Square Hilton
255 Mason St,, San Francisco, CA 94102-2114
D
San Francisco Greyhound Station
200 Folsom St, San Francisco, CA 94105
E
444 Townsend St.
444 Townsend St, San Francisco, CA 94107, USA

Compare bus companies

Amtrak

4/55,607 reviews

Staff4.7

Timeliness3.8

Cleanliness4.6

Wifi3.6

Greyhound

3.5/587,396 reviews

Staff3.6

Timeliness2.9

Cleanliness3.3

Wifi2.4

Greyhound Lines offers the most comprehensive intercity bus services in the United States. They operate a modern, environmentally friendly fleet that serves more than 2400 destinations and carries nearly 16 million passengers annually. When traveling with them, you can expect free WiFi, onboard entertainment, bathrooms, power outlets and decent legroom. One of the great perks of Greyhound is that they connect big cities and smaller towns in the US, where you usually can't get to by train or plane. If you're looking for safe and affordable transportation, Greyhound is a great choice.

Greyhound Medford San Francisco recent customer reviews

Very much unclear on the GPS tracker what actual time the bus is leaving. Kept changing. This why I had to be waiting in the cold for over 3 hours. Never been on a greyhound trip with them being on time!!

Sanneke U.

March 17, 2019

Really disappointed,the bus was two hours late ,and we booked the one in the midnight ,and we did not get on the bus till 02:35am.

Shin Wei Y.

September 28, 2018

Very comfortable bus and staff was helpful

Tural O.

October 1, 2019

US bus companies: FlixBus, BlaBlaCar Bus, ALSA, Greyhound, Intercape, Trenitalia, Sindbad

Frequently asked questions about traveling from Medford, OR to San Francisco, US by bus

What is the travel distance from Medford to San Francisco?
What are the departure and arrival stations when taking the bus from Medford to San Francisco?
What are the best sights and things to do in San Francisco?

Find cheapest prices for buses

Price is for a one-way ticket for one passenger and based on past searches.

Best price found

11/24

$163

11/25

No data

Today

No data

11/27

$137

11/28

No data

11/29

No data

11/30

No data

12/01

No data

The cheapest trip from Medford, OR to San Francisco, US was searched and found on Nov 27, 2025 with a price of $137

To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Medford, OR to San Francisco, US, as early as possible.

You can expect to pay from $137 to $628 for a bus ticket from Medford, OR to San Francisco, US based on the last 2 days. You can expect to find the cheapest price for the trip at $137 which is on 2025-11-27.