Next departures for Chicago to San Antonio on November 26
Operated by
Vehicle type
Departure time
Departure location
Trip duration
Arrival time
Arrival location
Recommended
Price and booking link
Greyhound Lines, Inc. + FlixBus
Bus
Chicago 95Th & Dan Ryan
Pearl District
Cheapest
Greyhound Lines, Inc. + Greyhound Lines Mexico
Bus
Downtown Greyhound Station
San Antonio Bus Station
Fastest
Greyhound Lines, Inc. + FlixBus
Bus
Downtown Greyhound Station
Pearl District
No tags
Greyhound Lines, Inc. + Greyhound Lines Mexico
Bus
537-517 W. Jackson Blvd
San Antonio Bus Station
No tags
FlixBus + Greyhound Lines, Inc. + Valley Transit
Bus
Chicago 95Th & Dan Ryan
San Antonio Bus Station
No tags
Next departures for Chicago to San Antonio on November 27
Operated by
Vehicle type
Departure time
Departure location
Trip duration
Arrival time
Arrival location
Recommended
Price and booking link
FlixBus + Greyhound Lines, Inc.
Bus
Chicago 95Th & Dan Ryan
Pearl District
Cheapest
Tornado Bus + Expreso
Bus
Chicago, IL
Tornado I-35
Fastest
FlixBus + Greyhound Lines, Inc. + Valley Transit
Bus
Downtown Greyhound Station
San Antonio Bus Station
No tags
Greyhound Lines, Inc. + Greyhound Lines Mexico
Bus
Downtown Greyhound Station
San Antonio Bus Station
No tags
FlixBus + Greyhound Lines, Inc.
Bus
Downtown Greyhound Station
Pearl District
No tags
Next departures for Chicago to San Antonio on November 28
Operated by
Vehicle type
Departure time
Departure location
Trip duration
Arrival time
Arrival location
Recommended
Price and booking link
FlixBus + Greyhound Lines, Inc. + Valley Transit
Bus
Chicago 95Th & Dan Ryan
San Antonio Bus Station
Cheapest
Tornado Bus + Expreso
Bus
Chicago, IL
Tornado I-35
Fastest
FlixBus + Greyhound Lines, Inc. + Valley Transit
Bus
Downtown Greyhound Station
San Antonio Bus Station
No tags
Greyhound Lines, Inc. + Greyhound Lines Mexico
Bus
Downtown Greyhound Station
San Antonio Bus Station
No tags
FlixBus + Greyhound Lines, Inc.
Bus
Downtown Greyhound Station
Pearl District
No tags
Next departures for Chicago to San Antonio on November 29
Operated by
Vehicle type
Departure time
Departure location
Trip duration
Arrival time
Arrival location
Recommended
Price and booking link
Bus
Chicago, IL
Tornado I-35
Cheapest
Tornado Bus + Expreso
Bus
Chicago, IL
Tornado I-35
Fastest
FlixBus + Greyhound Lines, Inc. + Valley Transit
Bus
Downtown Greyhound Station
San Antonio Bus Station
No tags
Greyhound Lines, Inc. + Greyhound Lines Mexico
Bus
Downtown Greyhound Station
San Antonio Bus Station
No tags
FlixBus + Greyhound Lines, Inc.
Bus
Downtown Greyhound Station
Pearl District
No tags
Next departures for Chicago to San Antonio on November 30
Operated by
Vehicle type
Departure time
Departure location
Trip duration
Arrival time
Arrival location
Recommended
Price and booking link
FlixBus + Greyhound Lines, Inc. + Valley Transit
Bus
Chicago 95Th & Dan Ryan
San Antonio Bus Station
Cheapest
Tornado Bus + Expreso
Bus
Chicago, IL
Tornado I-35
Fastest
FlixBus + Greyhound Lines, Inc. + Valley Transit
Bus
Downtown Greyhound Station
San Antonio Bus Station
No tags
Greyhound Lines, Inc. + Greyhound Lines Mexico
Bus
Downtown Greyhound Station
San Antonio Bus Station
No tags
FlixBus + Greyhound Lines, Inc.
Bus
Downtown Greyhound Station
Pearl District
No tags
Next departures for Chicago to San Antonio on December 1
Operated by
Vehicle type
Departure time
Departure location
Trip duration
Arrival time
Arrival location
Recommended
Price and booking link
FlixBus + Greyhound Lines, Inc. + Valley Transit
Bus
Chicago 95Th & Dan Ryan
San Antonio Bus Station
Cheapest
Tornado Bus + Expreso
Bus
Chicago, IL
Tornado I-35
Fastest
FlixBus + Greyhound Lines, Inc. + Valley Transit
Bus
Downtown Greyhound Station
San Antonio Bus Station
No tags
Greyhound Lines, Inc. + Greyhound Lines Mexico
Bus
Downtown Greyhound Station
San Antonio Bus Station
No tags
FlixBus + Greyhound Lines, Inc.
Bus
Downtown Greyhound Station
Pearl District
No tags
Next departures for Chicago to San Antonio on December 2
Operated by
Vehicle type
Departure time
Departure location
Trip duration
Arrival time
Arrival location
Recommended
Price and booking link
FlixBus + Greyhound Lines, Inc. + Valley Transit
Bus
Chicago 95Th & Dan Ryan
San Antonio Bus Station
Cheapest
Tornado Bus + Expreso
Bus
Chicago, IL
Tornado I-35
Fastest
Greyhound Lines, Inc. + Valley Transit
Bus
Downtown Greyhound Station
San Antonio Bus Station
No tags
Greyhound Lines, Inc. + Greyhound Lines Mexico
Bus
Downtown Greyhound Station
San Antonio Bus Station
No tags
FlixBus + Greyhound Lines, Inc. + Greyhound Lines Mexico
Bus
Chicago 95Th & Dan Ryan
San Antonio Bus Station
No tags
Next departures for Chicago to San Antonio on December 3
Operated by
Vehicle type
Departure time
Departure location
Trip duration
Arrival time
Arrival location
Recommended
Price and booking link
FlixBus + Greyhound Lines, Inc.
Bus
Chicago 95Th & Dan Ryan
Pearl District
Cheapest
Tornado Bus + Expreso
Bus
Chicago, IL
Tornado I-35
Fastest
Greyhound Lines, Inc. + Valley Transit
Bus
Downtown Greyhound Station
San Antonio Bus Station
No tags
Greyhound Lines, Inc. + Greyhound Lines Mexico
Bus
Downtown Greyhound Station
San Antonio Bus Station
No tags
Greyhound Lines, Inc. + FlixBus
Bus
Downtown Greyhound Station
Pearl District
No tags
Last refresh of the prices: Yesterday at 9:08 PM CST.
Compare 2 ways to go from Chicago to San Antonio
We recommend taking the bus
Among the sustainable travel choices, the bus stands out as a good way to reach San Antonio. The journey takes about 1 day, 3 hours 10 minutes, and with fares starting at just $147, it presents an excellent value for a comfortable ride.
Based on 156 reviews, the company was rated 3.1 stars on Busbud. Travellers were especially satisfied with the value for money and the ticket access but often complained with the timeliness. Tornado Bus ticket prices on this trip start at $372
Based on 87397 reviews, the company was rated 3.5 stars on Busbud. Travellers were especially satisfied with the ticket access and the temperature but often complained with the WiFi. Greyhound ticket prices on this trip start at $124
Based on 11449 reviews, the company was rated 3.5 stars on Busbud. Travellers were especially satisfied with the ticket access and the staff but often complained with the WiFi. FlixBus ticket prices on this trip start at $124
Frequently asked questions about travelling from Chicago to San Antonio, US by bus
What is the distance between Chicago and San Antonio?
The distance between Chicago and San Antonio is around 1693 km (1050 miles).
What are the departure and arrival locations for buses traveling from Chicago to San Antonio?
Buses traveling this route start their trip at Downtown Greyhound Station, in Chicago, and end it at Tornado I-35, in San Antonio.
Find cheapest prices for buses
Price is for a one-way ticket for one passenger and based on past searches.
Best price found
11-24
$398
11-25
$398
Today
$398
11-27
$398
11-28
$398
11-29
$398
11-30
$398
12-01
$398
The cheapest trip from Chicago to San Antonio, US was searched and found on Nov 24, 2025 with a price of $398
To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Chicago to San Antonio, US, as early as possible.
You can expect to pay from $398 to $419 for a bus ticket from Chicago to San Antonio, US based on the last 2 days. You can expect to find the cheapest price for the trip at $398 which is on 2025-11-27.