Next departures for Florence to Chicago on November 21
Operated by
Vehicle type
Departure time
Departure location
Trip duration
Arrival time
Arrival location
Recommended
Price and booking link
Train
Florence Station
Chicago (Union Station), IL
CheapestFastest
Train
Florence Station
Chicago (Union Station), IL
No tags
Train
Florence Station
Chicago (Union Station), IL
No tags
Train
Florence Station
Chicago (Union Station), IL
No tags
Last refresh of the prices: Today at 9:43 AM EST.
Compare 2 ways to go from Florence to Chicago
We recommend taking the bus
Among the sustainable travel choices, the bus stands out as the good way to reach Chicago. The journey takes about 1 day, 4 hours 55 minutes and with fares starting at just $124, it presents an excellent value for a comfortable ride.
Based on 5597 reviews, the company was rated 4.1 stars on Busbud. Travelers were especially satisfied with the seats and the ticket access but often complained with the wifi. Amtrak ticket prices on this trip start at $186
Frequently asked questions about traveling from Florence, SC, US to Chicago by train
How much does a train ticket from Florence to Chicago cost?
The average train ticket price from Florence to Chicago is $383. The best way to find train tickets from Florence to Chicago is to book your tickets as early as possible. Prices tend to rise as your travel date approaches, so book in advance to secure the best prices!
How long is the train trip from Florence to Chicago?
A train trip between Florence and Chicago is around 1d 11h, although the fastest train will take about 1d 10h. This is the time it takes to travel the 684 miles that separates the two cities.
How many daily trains are there between Florence and Chicago?
The number of trains from Florence to Chicago can differ depending on the day of the week. On average, there are 2. Some trains are direct while others have layovers. Simplify your train trip from Florence to Chicago by comparing and selecting the train that fits your travel style and budget on Busbud.
Which train companies travel from Florence to Chicago?
When taking the train from Florence to Chicago, you can travel comfortably and safely with Amtrak.
What are the best sights and things to do in Chicago?
Once in Chicago, you can explore the city. The top sights and things to do are Museum of Contemporary Art, Willis Tower (Sears Tower), Chicago Shakespeare Theater on Navy Pier, Navy Pier, Lincoln Park Zoo.
Find cheapest prices for trains
Price is for a one-way ticket for one passenger and based on past searches.
Best price found
11/18
No data
11/19
No data
Today
$493
11/21
$493
11/22
No data
11/23
No data
11/24
No data
11/25
$339
The cheapest trip from Florence, SC, US to Chicago was searched and found on Nov 25, 2025 with a price of $339
To save money and be sure you have the best seat, it's a good idea to buy your train tickets from Florence, SC, US to Chicago, as early as possible.
You can expect to pay from $339 to $2,031 for a train ticket from Florence, SC, US to Chicago based on the last 2 days. You can expect to find the cheapest price for the trip at $339 which is on 2025-11-25.
The cheapest trip from Florence, SC, US to Chicago was searched and found on Nov 25, 2025 with a price of $339
