Next bus departures
| Operated by | Vehicle type | Departure time | Departure location | Trip duration | Arrival time | Arrival location | Recommended | Price and booking link |
|---|---|---|---|---|---|---|---|---|
 | Bus | Santa Fe Speedway Gas Station | Cross Border Xpress CBX (USA) | CheapestFastest | ||||
| Bus | Santa Fe Speedway Gas Station | Cross Border Xpress CBX (USA) | No tags | ||||
| Bus | Santa Fe Speedway Gas Station | Cross Border Xpress CBX (USA) | No tags |
Last refresh of the prices: Last Monday at 7:46 PM MST.
Get from Santa Fe to San Diego
The journey takes about 1 day, 4 hours 25 minutes and with fares starting at just $230, it presents an excellent value for a comfortable ride.
Where are the popular stops in Santa Fe and San Diego?
Stops in Santa Fe
- ASanta Fe Amtrak Station, Santa Fe, NM 87501, USA
- BSanta Fe Amtrak Bus Stop, New Mexico 87506, USA
Stops in San Diego
- A
Mission Valley Sheraton
1433 Camino del Rio S, San Diego, CA 92108, USA - B
Old Town Courtyard Marriot
2435 Jefferson St, San Diego, CA 92110, USA - C
Downtown Holiday Inn
1617 1st Ave, San Diego, CA 92101, USA - D
Greyhound Station
1313 National Ave, San Diego, CA 92101, USA - E
Market St. & Park Blvd
601 Park Boulevard, San Diego, CA 92101, USA - F
San Ysidro McDonald's
727 E San Ysidro Blvd, San Diego, CA 92173, USA
Compare bus companies
Based on 272 reviews, the company was rated 3.3 stars on Busbud. Travelers were especially satisfied with the ticket access and the staff but often complained with the wifi. Los Limousines ticket prices on this trip start at $230
Frequently asked questions about traveling from Santa Fe, US to San Diego, CA, US by bus
Please note that schedules, routes, or operator details shown here may be updated or vary at the time of your trip.
How much is the bus ticket from Santa Fe to San Diego?
The cheapest bus tickets from Santa Fe to San Diego start from $230. The average price for this route is around $233. Busbud recommends that you book your tickets in advance for a better chance to get the lowest possible price.
How long is the bus ride from Santa Fe to San Diego?
The average bus trip duration from Santa Fe to San Diego is 1d 4h, covering a distance of 664 miles (1071 km). The quickest bus can get you there in 1d 2h and is operated by Los Limousines.
Which bus companies service the Santa Fe to San Diego route?
Several major train operators operate on this route with 3 trains available per day.
What is the earliest and latest departure time for the bus from Santa Fe to San Diego?
The earliest bus departs from Santa Fe to San Diego at 1:35am. And the latest bus departs at 1:35am.
What are the CO₂ emissions for the bus trip from Santa Fe to San Diego?
A bus trip from Santa Fe to San Diego generates an estimated 27 kg of CO₂, making it a highly eco-friendly travel option and recommended mode of travel by Busbud.
Find cheapest prices for buses
Price is for a one-way ticket for one passenger and based on past searches.
The cheapest trip from Santa Fe, US to San Diego, CA, US was searched and found on Nov 30, 2025 with a price of $227To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Santa Fe, US to San Diego, CA, US, as early as possible.
You can expect to pay from $227 to $229 for a bus ticket from Santa Fe, US to San Diego, CA, US based on the last 2 days. You can expect to find the cheapest price for the trip at $227 which is on 2025-11-30.
