Next bus departures
| Operated by | Vehicle type | Departure time | Departure location | Trip duration | Arrival time | Arrival location | Recommended | Price and booking link |
|---|---|---|---|---|---|---|---|---|
 | Bus | Santa Fe Speedway Gas Station | Cross Border Xpress CBX (USA) | CheapestFastest | ||||
| Bus | Santa Fe Speedway Gas Station | Cross Border Xpress CBX (USA) | No tags | ||||
| Bus | Santa Fe Speedway Gas Station | Cross Border Xpress CBX (USA) | No tags |
Last refresh of the prices: Yesterday at 7:46 PM MST.
Get from Santa Fe to San Diego
The journey takes about 1 day, 4 hours 25 minutes, and with fares starting at just $333, it presents an excellent value for a comfortable ride.
Where are the popular stops in Santa Fe and San Diego?
Stops in Santa Fe
- ASanta Fe Amtrak Station, Santa Fe, NM 87501, USA
- BSanta Fe Amtrak Bus Stop, New Mexico 87506, USA
Stops in San Diego
- A
Mission Valley Sheraton
1433 Camino del Rio S, San Diego, CA 92108, USA - B
Old Town Courtyard Marriot
2435 Jefferson St, San Diego, CA 92110, USA - C
Downtown Holiday Inn
1617 1st Ave, San Diego, CA 92101, USA - D
Greyhound Station
1313 National Ave, San Diego, CA 92101, USA - E
Market St. & Park Blvd
601 Park Boulevard, San Diego, CA 92101, USA - F
San Ysidro McDonald's
727 E San Ysidro Blvd, San Diego, CA 92173, USA
Compare bus companies
Based on 268 reviews, the company was rated 3.3 stars on Busbud. Travellers were especially satisfied with the ticket access and the staff but often complained with the WiFi. Los Limousines ticket prices on this trip start at $333
Frequently asked questions about travelling from Santa Fe, US to San Diego, CA, US by bus
What is the travel distance from Santa Fe to San Diego?
The distance between Santa Fe and San Diego is approximately 1084 km (672 miles).
What are the departure and arrival locations for buses traveling from Santa Fe to San Diego?
Buses departing from Santa Fe Station in Santa Fe will take you to Mission Valley Sheraton in San Diego.
Find cheapest prices for buses
Price is for a one-way ticket for one passenger and based on past searches.
The cheapest trip from Santa Fe, US to San Diego, CA, US was searched and found on Nov 30, 2025 with a price of $329To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Santa Fe, US to San Diego, CA, US, as early as possible.
You can expect to pay from $329 to $329 for a bus ticket from Santa Fe, US to San Diego, CA, US based on the last 2 days. You can expect to find the cheapest price for the trip at $329 which is on 2025-11-30.
