Previously seen trips
| Operated by | Vehicle type | Departure time | Departure location | Trip duration | Arrival time | Arrival location | Recommended | Price and booking link |
|---|---|---|---|---|---|---|---|---|
Greyhound + FlixBus | Bus | San Diego (Old Town-FlixBus) | Gateway Station | No tags | ||||
Greyhound + FlixBus | Bus | UCSD Health La Jolla Station | Gateway Station | No tags | ||||
FlixBus + Greyhound | Bus | UCSD Health La Jolla Station | St Louis, MO | No tags | ||||
 | Bus | Greyhound Bus Stop | Gateway Station | No tags | ||||
| Bus | Greyhound Bus Stop | St Louis, MO | No tags |
Compare 2 ways to go from San Diego to St. Louis
Among the sustainable travel choices, the bus stands out as the good way to reach St. Louis. The journey takes about 1 day, 21 hours 15 minutes and with fares starting at just $138, it presents an excellent value for a comfortable ride.
Where are the popular stops in San Diego and St. Louis?
Stops in San Diego
- A
Mission Valley Sheraton
1433 Camino del Rio S, San Diego, CA 92108, USA - B
Old Town Courtyard Marriot
2435 Jefferson St, San Diego, CA 92110, USA - C
Downtown Holiday Inn
1617 1st Ave, San Diego, CA 92101, USA - D
Greyhound Station
1313 National Ave, San Diego, CA 92101, USA - E
Market St. & Park Blvd
601 Park Boulevard, San Diego, CA 92101, USA - F
San Ysidro McDonald's
727 E San Ysidro Blvd, San Diego, CA 92173, USA
Compare bus companies
Frequently asked questions about traveling from San Diego, CA, US to St. Louis by bus
Please note that schedules, routes, or operator details shown here may be updated or vary at the time of your trip.
How much is the bus ticket from San Diego to St. Louis?
The cheapest bus tickets from San Diego to St. Louis start from $138. The average price for this route is around $276. Busbud recommends that you book your tickets in advance for a better chance to get the lowest possible price.
How long is the bus ride from San Diego to St. Louis?
The average bus trip duration from San Diego to St. Louis is 1d 21h, covering a distance of 1559 miles (2514 km). The quickest bus can get you there in 1d 19h and is operated by Greyhound.
Which bus companies service the San Diego to St. Louis route?
What is the earliest and latest departure time for the bus from San Diego to St. Louis?
The earliest bus departs from San Diego to St. Louis at 6:45am. And the latest bus departs at 7:35pm.
What are the CO₂ emissions for the bus trip from San Diego to St. Louis?
A bus trip from San Diego to St. Louis generates an estimated 63 kg of CO₂, making it a highly eco-friendly travel option and recommended mode of travel by Busbud.
What is the best bus company from San Diego to St. Louis?
According to Busbud customers, the highest-rated bus company on this route is Greyhound, with an average rating of 3.5 out of 5 stars based on 87435 reviews.
Which bus company has the best Wi-Fi from San Diego to St. Louis?
Based on reviews on Busbud, the bus company FlixBus has the best Wi-Fi rating with a score of 2.7.
Which bus company has the most timely service from San Diego to St. Louis?
According to Busbud traveller reviews, the most timely bus company on this route is FlixBus, with a punctuality rating of 3.9 out of 5 stars.
Which bus company has the cleanest buses from San Diego to St. Louis?
According to Busbud traveller reviews, the bus company with the cleanest buses on this route is FlixBus, with a cleanliness rating of 4.1 out of 5 stars.
Find cheapest prices for buses
Price is for a one-way ticket for one passenger and based on past searches.
The cheapest trip from San Diego, CA, US to St. Louis was searched and found on Dec 25, 2025 with a price of $154To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from San Diego, CA, US to St. Louis, as early as possible.
You can expect to pay from $154 to $435 for a bus ticket from San Diego, CA, US to St. Louis based on the last 2 days. You can expect to find the cheapest price for the trip at $154 which is on 2025-12-25.
What's the cheapest way to go from San Diego, CA, US to St. Louis?
The bus is the cheapest travel choice for this destination
