Bus Tickets from San Diego, CA, US to St. Louis

Previously seen trips

Next departures for San Diego to St. Louis on October 23
Operated byVehicle typeDeparture timeDeparture locationTrip durationArrival timeArrival locationRecommendedPrice and booking link
Greyhound + FlixBus
UCSD Health La Jolla Station
Gateway StationNo tags
FlixBus + Greyhound
UCSD Health La Jolla Station
Gateway StationNo tags
FlixBus + Greyhound
UCSD Health La Jolla Station
St Louis, MONo tags
Greyhound
Greyhound Bus Stop
Gateway StationNo tags
Greyhound
Greyhound Bus Stop
Gateway StationNo tags

Accepted payments

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  • JCB payment
  • Klarna (Pay over time)
  • Google Pay

Compare 2 ways to go from San Diego to St. Louis

busbud logoWe recommend taking the bus

Among the sustainable travel choices, the bus stands out as the good way to reach St. Louis. The journey takes about 1 day, 21 hours 35 minutes and with fares starting at just $132, it presents an excellent value for a comfortable ride.

7bus per day
1d 21hAverage Duration
1559 milesDistance
63kgCO₂ emissions
Bus
Average Price$132 - $431Average Duration1d 21h
63kg CO₂e
Train
Average Price$202 - $473Average Duration2d 6h
229kg CO₂e

Bus San Diego, CA, US to St. Louis: Trip Overview

Average ticket price$232
Average bus trip duration1d 21h
Number of daily buses7
Earliest bus departure6:45am
Distance1559 miles (2513 km)
Latest bus departure7:35pm

San Diego to St. Louis Bus

Busbud shows you the best bus ticket fares and bus schedules so you can easily plan and book a trip by bus from San Diego to St. Louis.

We make sure you can find a bus service from San Diego to St. Louis from the most reliable bus companies operating this trip.

From cheap bus tickets to more luxurious buses traveling from San Diego to St. Louis, we offer a wide range of bus services to best suit your needs depending on how much your budget is.

Frequently asked questions for your trip San Diego, CA, US - St. Louis

Find cheapest prices for buses

Price is for a one-way ticket for one passenger and based on past searches.

Best price found
10/20
$301
10/21
$234
Today
$279
10/23
$133
10/24
No data
10/25
No data
10/26
No data
10/27
No data
busbud logoThe cheapest trip from San Diego, CA, US to St. Louis was searched and found on Oct 23, 2025 with a price of $133

To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from San Diego, CA, US to St. Louis, as early as possible.

You can expect to pay from $133 to $301 for a bus ticket from San Diego, CA, US to St. Louis based on the last 2 days. You can expect to find the cheapest price for the trip at $133 which is on 2025-10-23.

About Bus Travel

Bus Travel Tips

If you're abroad, study some local language. Not only could it get you out of a pickle during your bus trip from San Diego to St. Louis but it'll also be endearing to native speakers who will surely appreciate your effort.

Start sightseeing the minute your bus leaves the station. If you're on the night bus from San Diego to St. Louis, get comfy and count the stars.

Taking the bus creates the smallest carbon footprint compared to other modes of transport. Not to mention that buses will allow you to discover scenic gems from San Diego to St. Louis that are otherwise impossible to come by with a plane.

Tune out to the fine sounds of your best music playlist on your bus trip from San Diego to St. Louis while indulging in miles on end of beautiful scenic views.

Did you know?

The average number of passengers on a coach bus is 32 meaning that a bus could replace a minimum of at least 30 cars!

Did you know that 80% of the buses in North America are equipped with WiFi and power outlets ? And 60% of bus travelers have used their electronic device on board during 2014.

One of the longest bus route in the world goes all the way from Ontario to Alberta in Canada (with the same bus). This trip is 3,435 km or 2,135 miles long and the price is a bit under $100.

What's the cheapest way to go from San Diego, CA, US to St. Louis?

busbud logoThe bus is the cheapest travel choice for this destination

Will you be returning to San Diego, CA, US by bus?

Bus from St. Louis to San Diego, CA, US

You can also go to St. Louis by train

Train from San Diego, CA, US to St. Louis

Why choose Busbud?

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Busbud makes bus travel easy. We help travelers find a bus, plot routes, and book intercity bus tickets all over the world. With several language and currency options available, Busbud seeks to cater to international bus travelers no matter where they are in the world. Busbud prides itself on its worldwide partnerships. We make it possible for you to buy tickets with its large network of trustworthy bus partners like Greyhound, Eurolines, ALSA, OUIBUS (BlaBlaBus), National Express and many others.

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