Next bus departures
| Operated by | Vehicle type | Departure time | Departure location | Trip duration | Arrival time | Arrival location | Recommended | Price and booking link |
|---|---|---|---|---|---|---|---|---|
FlixBus + Greyhound Lines, Inc. | Bus | San Diego (Old Town-FlixBus) | Des Moines | Cheapest | ||||
FlixBus + Greyhound Lines, Inc. | Bus | UCSD Health La Jolla Station | Des Moines | Fastest | ||||
 | Bus | Greyhound Bus Stop | Des Moines | No tags | ||||
FlixBus + Greyhound Lines, Inc. | Bus | Downtown SD (Seaport) | Des Moines | No tags |
Last refresh of the prices: Last Tuesday at 4:04 PM PST.
Get from San Diego to Des Moines
The journey takes about 1 day, 17 hours 20 minutes and with fares starting at just $226, it presents an excellent value for a comfortable ride.
Where are the popular stops in San Diego and Des Moines?
Stops in San Diego
- A
Mission Valley Sheraton
1433 Camino del Rio S, San Diego, CA 92108, USA - B
Old Town Courtyard Marriot
2435 Jefferson St, San Diego, CA 92110, USA - C
Downtown Holiday Inn
1617 1st Ave, San Diego, CA 92101, USA - D
Greyhound Station
1313 National Ave, San Diego, CA 92101, USA - E
Market St. & Park Blvd
601 Park Boulevard, San Diego, CA 92101, USA - F
San Ysidro McDonald's
727 E San Ysidro Blvd, San Diego, CA 92173, USA
Stops in Des Moines
- A
Jefferson/Trailways Depot
1501 2nd Ave North, Des Moines, IA 50314 - B
1514 East Grand Ave
1514 East Grand Avenue,, Des Moins, IA, 50316
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Frequently asked questions about traveling from San Diego, CA, US to Des Moines by bus
Please note that schedules, routes, or operator details shown here may be updated or vary at the time of your trip.
How much is the bus ticket from San Diego to Des Moines?
The cheapest bus tickets from San Diego to Des Moines start from $226. The average price for this route is around $229. Busbud recommends that you book your tickets in advance for a better chance to get the lowest possible price.
How long is the bus ride from San Diego to Des Moines?
The average bus trip duration from San Diego to Des Moines is 1d 17h, covering a distance of 1428 miles (2302 km). The quickest bus can get you there in 2d and is operated by Greyhound.
Which bus companies service the San Diego to Des Moines route?
What is the earliest and latest departure time for the bus from San Diego to Des Moines?
The earliest bus departs from San Diego to Des Moines at 6:45am. And the latest bus departs at 2:10pm.
What are the CO₂ emissions for the bus trip from San Diego to Des Moines?
A bus trip from San Diego to Des Moines generates an estimated 58 kg of CO₂, making it a highly eco-friendly travel option and recommended mode of travel by Busbud.
What is the best bus company from San Diego to Des Moines?
According to Busbud customers, the highest-rated bus company on this route is Greyhound, with an average rating of 3.5 out of 5 stars based on 87435 reviews.
Which bus company has the best Wi-Fi from San Diego to Des Moines?
Based on reviews on Busbud, the bus company FlixBus has the best Wi-Fi rating with a score of 2.7.
Which bus company has the most timely service from San Diego to Des Moines?
According to Busbud traveller reviews, the most timely bus company on this route is FlixBus, with a punctuality rating of 3.9 out of 5 stars.
Which bus company has the cleanest buses from San Diego to Des Moines?
According to Busbud traveller reviews, the bus company with the cleanest buses on this route is FlixBus, with a cleanliness rating of 4.1 out of 5 stars.
Find cheapest prices for buses
Price is for a one-way ticket for one passenger and based on past searches.
The cheapest trip from San Diego, CA, US to Des Moines was searched and found on Jan 3, 2026 with a price of $221To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from San Diego, CA, US to Des Moines, as early as possible.
You can expect to pay from $221 to $221 for a bus ticket from San Diego, CA, US to Des Moines based on the last 0 days. You can expect to find the cheapest price for the trip at $221 which is on 2026-01-03.
