Next departures for New York City to St. Louis on November 21
Operated by
Vehicle type
Departure time
Departure location
Trip duration
Arrival time
Arrival location
Recommended
Price and booking link
FlixBus + Greyhound Lines, Inc.
Bus
NYC Chinatown Lucky Star
Gateway Station
Cheapest
FlixBus + Greyhound Lines, Inc.
Bus
NYC Midtown (31st St & 8th Ave)
Gateway Station
Fastest
Bus
New York Port Authority
Gateway Station
No tags
FlixBus + Greyhound Lines, Inc.
Bus
New York (Hudson Yards)
Gateway Station
No tags
Bus
GW Bridge
Gateway Station
No tags
Next departures for New York City to St. Louis on November 22
Operated by
Vehicle type
Departure time
Departure location
Trip duration
Arrival time
Arrival location
Recommended
Price and booking link
Bus
New York Port Authority
Gateway Station
Cheapest
Bus
New York Port Authority
Gateway Station
Fastest
Bus
New York Port Authority
Gateway Station
No tags
FlixBus + Greyhound Lines, Inc.
Bus
NYC Midtown (31st St & 8th Ave)
Gateway Station
No tags
Bus
New York Port Authority
Gateway Station
No tags
Next departures for New York City to St. Louis on November 23
Operated by
Vehicle type
Departure time
Departure location
Trip duration
Arrival time
Arrival location
Recommended
Price and booking link
Bus
New York Port Authority
Gateway Station
Cheapest
Bus
New York Port Authority
Gateway Station
Fastest
Bus
New York Port Authority
Gateway Station
No tags
FlixBus + Greyhound Lines, Inc.
Bus
NYC Midtown (31st St & 8th Ave)
Gateway Station
No tags
Bus
New York Port Authority
Gateway Station
No tags
Next departures for New York City to St. Louis on November 24
Operated by
Vehicle type
Departure time
Departure location
Trip duration
Arrival time
Arrival location
Recommended
Price and booking link
Bus
New York Port Authority
Gateway Station
Cheapest
Bus
New York Port Authority
Gateway Station
Fastest
Bus
New York Port Authority
Gateway Station
No tags
FlixBus + Greyhound Lines, Inc.
Bus
NYC Midtown (31st St & 8th Ave)
Gateway Station
No tags
Bus
New York Port Authority
Gateway Station
No tags
Next departures for New York City to St. Louis on November 25
Operated by
Vehicle type
Departure time
Departure location
Trip duration
Arrival time
Arrival location
Recommended
Price and booking link
Bus
New York Port Authority
Gateway Station
Cheapest
Bus
New York Port Authority
Gateway Station
Fastest
Bus
New York Port Authority
Gateway Station
No tags
FlixBus + Greyhound Lines, Inc.
Bus
NYC Midtown (31st St & 8th Ave)
Gateway Station
No tags
Bus
New York Port Authority
Gateway Station
No tags
Next departures for New York City to St. Louis on November 26
Operated by
Vehicle type
Departure time
Departure location
Trip duration
Arrival time
Arrival location
Recommended
Price and booking link
Bus
New York Port Authority
Gateway Station
Cheapest
Bus
New York Port Authority
Gateway Station
Fastest
Bus
New York Port Authority
Gateway Station
No tags
FlixBus + Greyhound Lines, Inc.
Bus
NYC Midtown (31st St & 8th Ave)
Gateway Station
No tags
Bus
New York Port Authority
Gateway Station
No tags
Next departures for New York City to St. Louis on November 27
Operated by
Vehicle type
Departure time
Departure location
Trip duration
Arrival time
Arrival location
Recommended
Price and booking link
Bus
New York Port Authority
Gateway Station
Cheapest
Bus
New York Port Authority
Gateway Station
Fastest
Bus
New York Port Authority
Gateway Station
No tags
FlixBus + Greyhound Lines, Inc.
Bus
NYC Midtown (31st St & 8th Ave)
Gateway Station
No tags
Bus
New York Port Authority
Gateway Station
No tags
Next departures for New York City to St. Louis on November 28
Operated by
Vehicle type
Departure time
Departure location
Trip duration
Arrival time
Arrival location
Recommended
Price and booking link
Bus
New York Port Authority
Gateway Station
Cheapest
Bus
New York Port Authority
Gateway Station
Fastest
Bus
New York Port Authority
Gateway Station
No tags
FlixBus + Greyhound Lines, Inc.
Bus
NYC Midtown (31st St & 8th Ave)
Gateway Station
No tags
Bus
New York Port Authority
Gateway Station
No tags
Last refresh of the prices: Today at 7:33 AM EST.
Compare 2 ways to go from New York City to St. Louis
We recommend taking the bus
Among the sustainable travel choices, the bus stands out as the good way to reach St. Louis. The journey takes about 1 day, 4 hours 20 minutes and with fares starting at just $71, it presents an excellent value for a comfortable ride.
Greyhound Lines offers the most comprehensive intercity bus services in the United States. They operate a modern, environmentally friendly fleet that serves more than 2400 destinations and carries nearly 16 million passengers annually. When traveling with them, you can expect free WiFi, onboard entertainment, bathrooms, power outlets and decent legroom. One of the great perks of Greyhound is that they connect big cities and smaller towns in the US, where you usually can't get to by train or plane. If you're looking for safe and affordable transportation, Greyhound is a great choice.
Greyhound New York City St. Louis recent customer reviews
We were stranded in Dayton Ohio for 4 hrs because they overbooked the bus what kind of service is this there was no food and they didn't even apologize for inconvenience. We had to take a cab to get food and water
1 out of 5 stars
Gabrielle S.
Very organized company,driver was 3hrs late arriving at one pount
Flixbus is a European bus operator that offers intercity and bus travel in over 38 countries. Known for their easy-to-spot lime green buses and for offering affordable transportation between cities in Europe and the Americas, Flixbus is a good option for those looking for an affordable, reliable bus company. In their buses, you'll find free WiFi, bathrooms, and power outlets. You can also pay extra to choose your seat and get extra legroom, or even buy a snack or drink onboard directly from the driver. You can reschedule your ticket for a small fee, which varies from $1 to $5, depending on how close you are to the departure date.
Frequently asked questions about traveling from New York City to St. Louis by bus
How far is New York City from St. Louis?
The distance separating New York City and St. Louis is 871 miles (1405 km).
What are the departure and arrival stations when taking the bus from New York City to St. Louis?
Most of the buses traveling from New York City to St. Louis leave from Chinatown and arrive at Gateway Station. These are the most popular pick-up and drop-off locations on this route, but you can find others that could fit better into your travel plans.
What are the best sights and things to do in St. Louis?
Once in St. Louis, you can start exploring the city and discover its surroundings. The top sights and things to do are Saint Louis Zoo, Gateway Arch, Citygarden Sculpture Park, St. Louis Cardinals and Lumière Place.
Find cheapest prices for buses
Price is for a one-way ticket for one passenger and based on past searches.
Best price found
11/19
$109
11/20
$109
Today
$109
11/22
$102
11/23
$119
11/24
$135
11/25
$123
11/26
$143
The cheapest trip from New York City to St. Louis was searched and found on Nov 22, 2025 with a price of $102
To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from New York City to St. Louis, as early as possible.
You can expect to pay from $102 to $322 for a bus ticket from New York City to St. Louis based on the last 2 days. You can expect to find the cheapest price for the trip at $102 which is on 2025-11-22.
What's the cheapest way to go from New York City to St. Louis?
The bus is the cheapest travel choice for this destination