Bus from Milwaukee to St. Louis: Tickets & Schedules
Next bus departures
Next departures for Milwaukee to St. Louis on November 25
Operated by
Vehicle type
Departure time
Departure location
Trip duration
Arrival time
Arrival location
Recommended
Price and booking link
Bus
Milwaukee Mitchell MKE Airport
Gateway Station
CheapestFastest
Next departures for Milwaukee to St. Louis on November 27
Operated by
Vehicle type
Departure time
Departure location
Trip duration
Arrival time
Arrival location
Recommended
Price and booking link
Bus
Milwaukee Bus Station, St. Paul & N6th road.
Gateway Station
Cheapest
Greyhound Lines, Inc. + FlixBus
Bus
Milwaukee Bus Station, St. Paul & N6th road.
Gateway Station
Fastest
Bus
Milwaukee Bus Station, St. Paul & N6th road.
Gateway Station
No tags
Bus
Milwaukee Bus Station, St. Paul & N6th road.
Gateway Station
No tags
Bus
Milwaukee Mitchell MKE Airport
Gateway Station
No tags
Next departures for Milwaukee to St. Louis on December 1
Operated by
Vehicle type
Departure time
Departure location
Trip duration
Arrival time
Arrival location
Recommended
Price and booking link
FlixBus + Greyhound Lines, Inc.
Bus
Milwaukee Mitchell MKE Airport
Gateway Station
Cheapest
Greyhound Lines, Inc. + FlixBus
Bus
Milwaukee Bus Station, St. Paul & N6th road.
Gateway Station
Fastest
Bus
Milwaukee Bus Station, St. Paul & N6th road.
Gateway Station
No tags
Bus
Milwaukee Bus Station, St. Paul & N6th road.
Gateway Station
No tags
FlixBus + Greyhound Lines, Inc.
Bus
Milwaukee Bus Station, St. Paul & N6th road.
Gateway Station
No tags
Next departures for Milwaukee to St. Louis on December 2
Operated by
Vehicle type
Departure time
Departure location
Trip duration
Arrival time
Arrival location
Recommended
Price and booking link
FlixBus + Greyhound Lines, Inc.
Bus
Milwaukee Bus Station, St. Paul & N6th road.
Gateway Station
Cheapest
FlixBus + Greyhound Lines, Inc.
Bus
Milwaukee Mitchell MKE Airport
Gateway Station
Fastest
Bus
Milwaukee Bus Station, St. Paul & N6th road.
Gateway Station
No tags
FlixBus + Greyhound Lines, Inc.
Bus
Milwaukee Bus Station, St. Paul & N6th road.
Gateway Station
No tags
FlixBus + Greyhound Lines, Inc.
Bus
Milwaukee Mitchell MKE Airport
Gateway Station
No tags
Last refresh of the prices: Today at 8:42 AM CST.
Compare 2 ways to go from Milwaukee to St. Louis
We recommend taking the train
Among the sustainable travel choices, the train stands out as the good way to reach St. Louis. The journey takes about 8 hours 25 minutes and with fares starting at just $51, it presents an excellent value for a comfortable ride.
Flixbus is a European bus operator that offers intercity and bus travel in over 38 countries. Known for their easy-to-spot lime green buses and for offering affordable transportation between cities in Europe and the Americas, Flixbus is a good option for those looking for an affordable, reliable bus company. In their buses, you'll find free WiFi, bathrooms, and power outlets. You can also pay extra to choose your seat and get extra legroom, or even buy a snack or drink onboard directly from the driver. You can reschedule your ticket for a small fee, which varies from $1 to $5, depending on how close you are to the departure date.
Greyhound Lines offers the most comprehensive intercity bus services in the United States. They operate a modern, environmentally friendly fleet that serves more than 2400 destinations and carries nearly 16 million passengers annually. When traveling with them, you can expect free WiFi, onboard entertainment, bathrooms, power outlets and decent legroom. One of the great perks of Greyhound is that they connect big cities and smaller towns in the US, where you usually can't get to by train or plane. If you're looking for safe and affordable transportation, Greyhound is a great choice.
Frequently asked questions about traveling from Milwaukee to St. Louis by bus
What is the travel distance from Milwaukee to St. Louis?
About 328 miles (528 km) separate Milwaukee and St. Louis.
What are the departure and arrival stations when taking the bus from Milwaukee to St. Louis?
The majority of buses traveling from Milwaukee to St. Louis start their journey at Milwaukee Airport and wind up at Gateway Station. These are the main pick-up and drop-off locations on this route, there are other pick-up and drop-off locations that could make it easier for you to reach your destination.
What are the best sights and things to do in St. Louis?
Once in St. Louis, you can start exploring the city and discover its surroundings. The top sights and things to do are Missouri Botanical Garden, Old St. Louis County Courthouse, St. Louis Cardinals, Scott Joplin House State Historic Site and Citygarden Sculpture Park.
Find cheapest prices for buses
Price is for a one-way ticket for one passenger and based on past searches.
Best price found
11/23
$102
11/24
$95
Today
$95
11/26
$112
11/27
$68
11/28
$66
11/29
$69
11/30
$96
The cheapest trip from Milwaukee to St. Louis was searched and found on Nov 28, 2025 with a price of $66
To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Milwaukee to St. Louis, as early as possible.
You can expect to pay from $66 to $147 for a bus ticket from Milwaukee to St. Louis based on the last 2 days. You can expect to find the cheapest price for the trip at $66 which is on 2025-11-28.
Usually Greyhound, FlixBus will charge you higher prices for tickets closer to the departure date. To find the best prices, you should be flexible on your date of travel.
What's the cheapest way to go from Milwaukee to St. Louis?
The bus is the cheapest travel choice for this destination
The cheapest trip from Milwaukee to St. Louis was searched and found on Nov 28, 2025 with a price of $66
The bus is the cheapest travel choice for this destination
