Next departures for Milwaukee to La Crosse on November 25
Operated by
Vehicle type
Departure time
Departure location
Trip duration
Arrival time
Arrival location
Recommended
Price and booking link
Bus
St. Paul & N5th
632 17th Street North
CheapestFastest
Bus
Milwaukee Bus Station, St. Paul & N6th road.
La Crosse WI - University of Wisconsin (LSW)
No tags
Bus
St. Paul & N5th
La Crosse MTU Transit Center
No tags
Bus
Milwaukee Bus Station, St. Paul & N6th road.
La Crosse St Andrew St
No tags
Next departures for Milwaukee to La Crosse on November 26
Operated by
Vehicle type
Departure time
Departure location
Trip duration
Arrival time
Arrival location
Recommended
Price and booking link
Bus
St. Paul & N5th
632 17th Street North
CheapestFastest
Bus
Milwaukee Bus Station, St. Paul & N6th road.
La Crosse WI - University of Wisconsin (LSW)
No tags
Bus
St. Paul & N5th
La Crosse MTU Transit Center
No tags
Bus
Milwaukee Bus Station, St. Paul & N6th road.
La Crosse St Andrew St
No tags
Next departures for Milwaukee to La Crosse on November 27
Operated by
Vehicle type
Departure time
Departure location
Trip duration
Arrival time
Arrival location
Recommended
Price and booking link
Bus
Milwaukee Bus Station, St. Paul & N6th road.
La Crosse WI - University of Wisconsin (LSW)
CheapestFastest
Bus
Milwaukee Bus Station, St. Paul & N6th road.
La Crosse St Andrew St
No tags
Next departures for Milwaukee to La Crosse on November 28
Operated by
Vehicle type
Departure time
Departure location
Trip duration
Arrival time
Arrival location
Recommended
Price and booking link
Bus
St. Paul & N5th
632 17th Street North
CheapestFastest
Bus
Milwaukee Bus Station, St. Paul & N6th road.
La Crosse WI - University of Wisconsin (LSW)
No tags
Bus
St. Paul & N5th
La Crosse MTU Transit Center
No tags
Bus
Milwaukee Bus Station, St. Paul & N6th road.
La Crosse St Andrew St
No tags
Next departures for Milwaukee to La Crosse on November 29
Operated by
Vehicle type
Departure time
Departure location
Trip duration
Arrival time
Arrival location
Recommended
Price and booking link
Bus
St. Paul & N5th
632 17th Street North
CheapestFastest
Bus
Milwaukee Bus Station, St. Paul & N6th road.
La Crosse WI - University of Wisconsin (LSW)
No tags
Bus
St. Paul & N5th
La Crosse MTU Transit Center
No tags
Bus
Milwaukee Bus Station, St. Paul & N6th road.
La Crosse St Andrew St
No tags
Next departures for Milwaukee to La Crosse on November 30
Operated by
Vehicle type
Departure time
Departure location
Trip duration
Arrival time
Arrival location
Recommended
Price and booking link
Bus
St. Paul & N5th
632 17th Street North
CheapestFastest
Bus
Milwaukee Bus Station, St. Paul & N6th road.
La Crosse WI - University of Wisconsin (LSW)
No tags
Bus
St. Paul & N5th
La Crosse MTU Transit Center
No tags
Bus
Milwaukee Bus Station, St. Paul & N6th road.
La Crosse St Andrew St
No tags
Next departures for Milwaukee to La Crosse on December 1
Operated by
Vehicle type
Departure time
Departure location
Trip duration
Arrival time
Arrival location
Recommended
Price and booking link
Bus
St. Paul & N5th
632 17th Street North
CheapestFastest
Bus
Milwaukee Bus Station, St. Paul & N6th road.
La Crosse WI - University of Wisconsin (LSW)
No tags
Bus
St. Paul & N5th
La Crosse MTU Transit Center
No tags
Bus
Milwaukee Bus Station, St. Paul & N6th road.
La Crosse St Andrew St
No tags
Last refresh of the prices: Today at 12:09 AM CST.
Compare 2 ways to go from Milwaukee to La Crosse
We recommend taking the bus
Among the sustainable travel choices, the bus stands out as the good way to reach La Crosse. The journey takes about 4 hours 45 minutes and with fares starting at just $41, it presents an excellent value for a comfortable ride.
Traveling with Megabus from Milwaukee to La Crosse is an affordable and reliable way to reach your destination. The company provides amenities like comfortable seats and free Wi-Fi (on most buses), ensuring a comfortable journey. Discover an easy and budget-friendly travel option to La Crosse with Megabus. Tickets start at just $46, with an average price of around $51, making it an accessible choice for travelers.
Founded in 1919, Jefferson Lines provides bus services across the Midwest in the US. Their buses have WiFi, USB plugs, bathrooms, reclining seats, reading lights and GPS tracking. Tickets are non-refundable, but you can change the date by paying a fee. Known for their affordable prices and convenient schedules, if you're looking to travel in the Midwest, Jefferson Lines is the way to go.
Jefferson Lines Milwaukee La Crosse recent customer reviews
Frequently asked questions about traveling from Milwaukee to La Crosse, WI by bus
What is the distance between Milwaukee and La Crosse?
The distance separating Milwaukee and La Crosse is 176 miles (284 km).
Find cheapest prices for buses
Price is for a one-way ticket for one passenger and based on past searches.
Best price found
11/22
$43
11/23
$43
Today
$43
11/25
$39
11/26
$43
11/27
$43
11/28
$43
11/29
$43
The cheapest trip from Milwaukee to La Crosse, WI was searched and found on Nov 25, 2025 with a price of $39
To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Milwaukee to La Crosse, WI, as early as possible.
You can expect to pay from $39 to $54 for a bus ticket from Milwaukee to La Crosse, WI based on the last 2 days. You can expect to find the cheapest price for the trip at $39 which is on 2025-11-25.
What's the cheapest way to go from Milwaukee to La Crosse, WI?
The bus is the cheapest travel choice for this destination
The cheapest trip from Milwaukee to La Crosse, WI was searched and found on Nov 25, 2025 with a price of $39
The bus is the cheapest travel choice for this destination
