Next bus departures
| Operated by | Vehicle type | Departure time | Departure location | Trip duration | Arrival time | Arrival location | Recommended | Price and booking link |
|---|---|---|---|---|---|---|---|---|
 | Bus | Lugano | Prague (Central Bus Station Florenc) | Cheapest | ||||
| Bus | Lugano | Prague (Main Railway Station) | Fastest | ||||
| Bus | Lugano | PRG Airport | No tags | ||||
| Bus | Lugano | PRG Airport | No tags | ||||
| Bus | Lugano | PRG Airport | No tags |
Last refresh of the prices: Last Wednesday at 6:48 PM CET.
Get from Lugano to Prague
The journey takes about 13 hours 20 minutes and with fares starting at just $50, it presents an excellent value for a comfortable ride.
Where are the popular stops in Lugano and Prague?
Stops in Lugano
- AVia Giacomo E Filippo Ciani, 6900 Lugano, Switzerland
- B
Stazione/Gare de Lugano
Stazione FFS 1, 6900 Lugano, Switzerland - C
Via Basilea
Via Basilea, 6900 Lugano, Switzerland
Stops in Prague
- AChlumecká, 198 00 Praha 20, Czech Republic
- BKřižíkova 2b, Nové Město, 186 00 Praha-Praha 8, Czech Republic
- CAviatická, 161 08, Praha 6, Czechia
- D
Zličín
Drahoňovského, 163 00 Praha 17, Czech Republic - ETomíčkova 2234, Chodov, 148 00 Praha-Praha 11, Czechia
- F300/8 Wilsonova, 110 00 Praha, Czechia
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Frequently asked questions about traveling from Lugano to Prague by bus
Please note that schedules, routes, or operator details shown here may be updated or vary at the time of your trip.
How much is the bus ticket from Lugano to Prague?
The cheapest bus tickets from Lugano to Prague start from $50. The average price for this route is around $73. Busbud recommends that you book your tickets in advance for a better chance to get the lowest possible price.
How long is the bus ride from Lugano to Prague?
The average bus trip duration from Lugano to Prague is 13h 20m, covering a distance of 378 miles (609 km). The quickest bus can get you there in 11h 35m and is operated by FlixBus.
Which bus companies service the Lugano to Prague route?
What is the earliest and latest departure time for the bus from Lugano to Prague?
The earliest bus departs from Lugano to Prague at 12:35am. And the latest bus departs at 11:00pm.
What are the CO₂ emissions for the bus trip from Lugano to Prague?
A bus trip from Lugano to Prague generates an estimated 15 kg of CO₂, making it a highly eco-friendly travel option and recommended mode of travel by Busbud.
What is the best bus company from Lugano to Prague?
According to Busbud customers, the highest-rated bus company on this route is RegioJet, with an average rating of 4.1 out of 5 stars based on 1062 reviews.
Which bus company has the best Wi-Fi from Lugano to Prague?
Based on reviews on Busbud, the bus company RegioJet has the best Wi-Fi rating with a score of 3.8.
Which bus company has the most timely service from Lugano to Prague?
According to Busbud traveller reviews, the most timely bus company on this route is RegioJet, with a punctuality rating of 4.0 out of 5 stars.
Which bus company has the cleanest buses from Lugano to Prague?
According to Busbud traveller reviews, the bus company with the cleanest buses on this route is RegioJet, with a cleanliness rating of 4.4 out of 5 stars.
Find cheapest prices for buses
Price is for a one-way ticket for one passenger and based on past searches.
The cheapest trip from Lugano to Prague was searched and found on Dec 22, 2025 with a price of $85To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Lugano to Prague, as early as possible.
You can expect to pay from $85 to $179 for a bus ticket from Lugano to Prague based on the last 2 days. You can expect to find the cheapest price for the trip at $86 which is on 2025-12-23.
