How far is Knoxville from Florence?

The distance separating Knoxville and Florence is 271 miles (436 km).

What are the departure and arrival stations when taking the bus from Knoxville to Florence?

Most of the buses traveling from Knoxville to Florence leave from 100 Kirkwood St and arrive at Florence Bus Station. These are the most popular departure and arrival locations on this route, but you could find others that could be a better fit for your travel plans.

What are the best sights and things to do in Florence?

Once in Florence, you can start exploring the city and discover its surroundings. The top sights and things to do are Villa Gamberaia, Tuscan Wine Tour, Galleria dell’Accademia, Cappella Brancacci and Santa Maria del Carmine and Cooking Classes in Florence.

Bus Knoxville to Florence from $128 | Compare & Save up to 20%

Previously seen trips

Next departures for Knoxville to Florence on November 12
Operated by	Vehicle type	Departure time	Departure location	Trip duration	Arrival time	Arrival location	Recommended
FlixBus + Greyhound	Bus	11:45pm	Knoxville Bus Station	1d	11:59pm	Florence, SC	No tags
Greyhound + FlixBus	Bus	11:45pm	Knoxville Bus Station	1d	11:59pm	Florence, SC	No tags
FlixBus + Greyhound	Bus	7:25pm	Knoxville Bus Station	1d 4h	12:05am	Florence, SC	No tags

Get from Knoxville to Florence

This route is served by bus only

The journey takes about 1 day, 4 hours 40 minutes and with fares starting at just $128, it presents an excellent value for a comfortable ride.

2bus per day

1d 4hAverage Duration

264 milesDistance

11kgCO₂ emissions

Where are the popular stops in Knoxville and Florence?

Stops in Knoxville

A - 100 Kirkwood St

Stops in Florence

A - Florence Bus Station

B - TA Travel Center - Florence

Frequently asked questions about traveling from Knoxville, TN to Florence, SC, US by bus

How far is Knoxville from Florence?
What are the departure and arrival stations when taking the bus from Knoxville to Florence?
What are the best sights and things to do in Florence?