Next departures for Karlsruhe to Brussels on November 19
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Recommended
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Bus
Südseite Hauptbahnhof
Brussels North Train Station
CheapestFastest
Bus
Südseite Hauptbahnhof
Brussels Airport
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Next departures for Karlsruhe to Brussels on November 21
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Bus
Karlsruhe
Brussels-South (Gare du Midi)
CheapestFastest
Next departures for Karlsruhe to Brussels on November 24
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Vehicle type
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Bus
Karlsruhe
Brussels-South (Gare du Midi)
Cheapest
Bus
Karlsruhe
Brussels-South (Gare du Midi)
Fastest
Last refresh of the prices: Today at 3:07 PM CET.
Compare 3 ways to go from Karlsruhe to Brussels
We recommend carpooling
Among the sustainable travel choices, the carpool stands out as the good way to reach Brussels. The journey takes about 4 hours 50 minutes and with fares starting at just $24, it presents an excellent value for a comfortable ride.
Flixbus is a European bus operator that offers intercity and bus travel in over 38 countries. Known for their easy-to-spot lime green buses and for offering affordable transportation between cities in Europe and the Americas, Flixbus is a good option for those looking for an affordable, reliable bus company. In their buses, you'll find free WiFi, bathrooms, and power outlets. You can also pay extra to choose your seat and get extra legroom, or even buy a snack or drink onboard directly from the driver. You can reschedule your ticket for a small fee, which varies from $1 to $5, depending on how close you are to the departure date.
Based on 11137 reviews, the company was rated 3.7 stars on Busbud. Travelers were especially satisfied with the ticket access and the staff but often complained with the wifi. BlaBlaCar Bus ticket prices on this trip start at $25
Frequently asked questions about traveling from Karlsruhe to Brussels by bus
What is the distance between Karlsruhe and Brussels?
The distance separating Karlsruhe and Brussels is 220 miles (355 km).
What are the departure and arrival stations when taking the bus from Karlsruhe to Brussels?
If you're headed to Brussels from Karlsruhe, chances are that your bus will leave from Südseite Hauptbahnhof and arrive at Brussels South (Gare du Midi). These are the most popular pick-up and drop-off locations on this route, there are other pick-up and drop-off locations that could make it easier for you to reach your destination.
What are the best sights and things to do in Brussels?
Once in Brussels, you can start exploring the city and discover its surroundings. The top sights and things to do are Visit the Laeken Royal Greenhouses in Brussels, Belgian Beer Weekend in Brussels! 20km of Brussels - 36 years of Brussels' most popular race, Bright Brussels Festival and The Iris events.
Find cheapest prices for buses
Price is for a one-way ticket for one passenger and based on past searches.
Best price found
11/16
$37
11/17
$58
Today
No data
11/19
$34
11/20
No data
11/21
$34
11/22
$24
11/23
$29
The cheapest trip from Karlsruhe to Brussels was searched and found on Nov 22, 2025 with a price of $24
To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Karlsruhe to Brussels, as early as possible.
You can expect to pay from $24 to $58 for a bus ticket from Karlsruhe to Brussels based on the last 2 days. You can expect to find the cheapest price for the trip at $24 which is on 2025-11-22.
The cheapest trip from Karlsruhe to Brussels was searched and found on Nov 22, 2025 with a price of $24
