What is the distance between Karlsruhe and Brussels?

The distance between Karlsruhe and Brussels is around 355 km (220 miles).

What are the departure and arrival locations for buses traveling from Karlsruhe to Brussels?

Buses traveling this route start their trip at Südseite Hauptbahnhof, in Karlsruhe, and end it at Brussels South (Gare du Midi), in Brussels.

Bus Karlsruhe to Brussels from $34 | Refundable Tickets

Next bus departures

Next departures for Karlsruhe to Brussels on November 19
Operated by	Vehicle type	Departure time	Departure location	Trip duration	Arrival time	Arrival location	Recommended	Price and booking link
	Bus	11:10pm	Südseite Hauptbahnhof	7h 35m	6:45am	Brussels North Train Station	CheapestFastest
	Bus	11:10pm	Südseite Hauptbahnhof	11h 40m	10:50am	Brussels Airport	No tags

Next departures for Karlsruhe to Brussels on November 21
Operated by	Vehicle type	Departure time	Departure location	Trip duration	Arrival time	Arrival location	Recommended	Price and booking link
	Bus	9:05pm	Karlsruhe	7h 50m	4:55am	Brussels-South (Gare du Midi)	CheapestFastest

Next departures for Karlsruhe to Brussels on November 24
Operated by	Vehicle type	Departure time	Departure location	Trip duration	Arrival time	Arrival location	Recommended	Price and booking link
	Bus	11:50am	Karlsruhe	14h 23m	2:13am	Brussels-South (Gare du Midi)	Cheapest
	Bus	3:05am	Karlsruhe	13h 25m	4:30pm	Brussels-South (Gare du Midi)	Fastest

Last refresh of the prices: Today at 3:07 PM CET.

Compare 3 ways to go from Karlsruhe to Brussels

We recommend carpooling

Among the sustainable travel choices, the carpool stands out as a good way to reach Brussels. The journey takes about 4 hours 50 minutes, and with fares starting at just $34, it presents an excellent value for a comfortable ride.

1carpool per day

4h 50mAverage Duration

355 kmDistance

15kgCO₂ emissions

	Average Price	Average Duration	CO₂ emissions
Bus	Average Price$36 - $220	Average Duration13h 5m	CO₂ emissions 9kg CO₂e
Train	Average Price$113 - $417	Average Duration6h 22m	CO₂ emissions 9kg CO₂e
Carpool	Average Price$34 - $53	Average Duration4h 50m	CO₂ emissions 15kg CO₂e

Compare bus companies

FlixBus

3.5/511,365 reviews

Staff4.1

Timeliness3.9

Cleanliness4.1

Wifi2.7

BlaBlaCar Bus

3.5/511,137 reviews

Staff4.4

Timeliness3.6

Cleanliness4.3

Wifi2.6

BE Bus Companies: FlixBus, BlaBlaCar Bus, ALSA, Greyhound, Intercape, Trenitalia, Sindbad

Where are the popular stops in Karlsruhe and Brussels?

Stops in Karlsruhe

A - Südseite Hauptbahnhof

B - Karlsruhe Hbf

C - Goethestraße

D - Karlsruhe

E - Karlsruhe/Baden-Baden Airport

Stops in Brussels

A - Brussels South (Gare du Midi)

B - Brux-Nord

C - Congrès

D - Centrale

Frequently asked questions about travelling from Karlsruhe to Brussels by bus

What is the distance between Karlsruhe and Brussels?
The distance between Karlsruhe and Brussels is around 355 km (220 miles).
What are the departure and arrival locations for buses traveling from Karlsruhe to Brussels?
Buses traveling this route start their trip at Südseite Hauptbahnhof, in Karlsruhe, and end it at Brussels South (Gare du Midi), in Brussels.

Find cheapest prices for buses

Price is for a one-way ticket for one passenger and based on past searches.

Best price found

11-16

$53

11-17

$82

Today

No data

11-19

$49

11-20

No data

11-21

$49

11-22

$34

11-23

$41

The cheapest trip from Karlsruhe to Brussels was searched and found on Nov 22, 2025 with a price of $34

To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Karlsruhe to Brussels, as early as possible.

You can expect to pay from $34 to $82 for a bus ticket from Karlsruhe to Brussels based on the last 2 days. You can expect to find the cheapest price for the trip at $34 which is on 2025-11-22.