Next bus departures
| Operated by | Vehicle type | Departure time | Departure location | Trip duration | Arrival time | Arrival location | Recommended | Price and booking link |
|---|---|---|---|---|---|---|---|---|
 | Bus | Südseite Hauptbahnhof | Brussels North Train Station | CheapestFastest | ||||
| Bus | Südseite Hauptbahnhof | Brussels Airport | No tags |
Last refresh of the prices: Today at 3:07 PM CET.
Compare 3 ways to travel from Karlsruhe to Brussels
Among the sustainable travel choices, the carpool stands out as a good way to reach Brussels. The journey takes about 4 hours 50 minutes and with fares starting at just R 413, it presents an excellent value for a comfortable ride.
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Where are the popular stops in Karlsruhe and Brussels?
Frequently asked questions about travelling from Karlsruhe to Brussels by bus
How much does a bus ticket from Karlsruhe to Brussels cost?
The bus ticket price from Karlsruhe to Brussels starts at R 438. The best way to find cheap bus tickets from Karlsruhe to Brussels is to book your tickets as early as possible. Prices tend to rise as your travel date approaches, so book in advance to secure the best prices!
How long is the bus ride from Karlsruhe to Brussels?
The average travel time between Karlsruhe and Brussels is around 13h 5m, although the fastest bus will take about 7h 30m. This is the time it takes to travel the 355 km that separates the two cities.
How many daily bus connections are there between Karlsruhe and Brussels?
The number of buses from Karlsruhe to Brussels can differ depending on the day of the week. On average, there are 2 on this route. Some buses run direct routes, while others have layovers. Simplify your bus trip from Karlsruhe to Brussels by comparing and selecting the bus that fits your travel style and budget on Busbud.
Which bus companies travel from Karlsruhe to Brussels?
When taking the bus from Karlsruhe to Brussels, you can travel comfortably and safely with FlixBus, BlaBlaCar Bus.
What are the departure and arrival stations when taking the bus from Karlsruhe to Brussels?
Buses travelling between Karlsruhe and Brussels leave from Südseite Hauptbahnhof or Karlsruhe Hbf and arrive at Brussels South (Gare du Midi), Brux-Nord, Congrès.
Find cheapest prices for buses
Price is for a one-way ticket for one passenger and based on past searches.
The cheapest trip from Karlsruhe to Brussels was searched and found on 22 Nov 2025 with a price of R 413To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Karlsruhe to Brussels as early as possible.
You can expect to pay from R 413 to R 1 006 for a bus ticket from Karlsruhe to Brussels based on the last 2 days. You can expect to find the cheapest price for the trip at R 413, which is on 2025-11-22.