What is the travel distance from Indianapolis to Knoxville?

The distance between the two cities is 290 miles (468 km).

What are the departure and arrival stations when taking the bus from Indianapolis to Knoxville?

Buses going from Indianapolis to Knoxville begin their journey at Greyhound Amtrak Station and reach their destination at 100 Kirkwood St.

Bus Indianapolis to Knoxville from $74 | Refundable Tickets

Previously seen trips

Next departures for Indianapolis to Knoxville on November 20
Operated by	Vehicle type	Departure time	Departure location	Trip duration	Arrival time	Arrival location	Recommended
Greyhound + FlixBus	Bus	10:30pm	Downtown Transit Center	23h 50m	10:20pm	Knoxville Bus Station	No tags
	Bus	3:50pm	Indianapolis Bus Station	10h 55m	2:45am	Knoxville Bus Station	No tags
	Bus	7:55pm	Indianapolis Bus Station	22h 40m	6:35pm	Knoxville Bus Station	No tags
FlixBus + Greyhound	Bus	11:30pm	Downtown Transit Center	22h 50m	10:20pm	Knoxville Bus Station	No tags
	Bus	7:30am	Indianapolis Bus Station	11h 25m	6:55pm	Knoxville Bus Station	No tags

Get from Indianapolis to Knoxville

This route is served by bus only

The journey takes about 11 hours 15 minutes and with fares starting at just $71, it presents an excellent value for a comfortable ride.

2bus per day

11h 15mAverage Duration

288 milesDistance

12kgCO₂ emissions

Where are the popular stops in Indianapolis and Knoxville?

Stops in Indianapolis

A
Greyhound Amtrak Station
350 S Illinois St, Indianapolis, IN 46225
Visit page

Stops in Knoxville

A
100 Kirkwood St
Knoxville Area Transit Bus Stop, 100 Kirkwood St, Knoxville, TN 37914, USA
Visit page

Compare bus companies

Greyhound

3.5/587,386 reviews

Staff3.6

Timeliness2.9

Cleanliness3.3

Wifi2.4

Greyhound Lines offers the most comprehensive intercity bus services in the United States. They operate a modern, environmentally friendly fleet that serves more than 2400 destinations and carries nearly 16 million passengers annually. When traveling with them, you can expect free WiFi, onboard entertainment, bathrooms, power outlets and decent legroom. One of the great perks of Greyhound is that they connect big cities and smaller towns in the US, where you usually can't get to by train or plane. If you're looking for safe and affordable transportation, Greyhound is a great choice.

FlixBus

3.5/511,388 reviews

Staff4.2

Timeliness3.9

Cleanliness4.1

Wifi2.7

Flixbus is a European bus operator that offers intercity and bus travel in over 38 countries. Known for their easy-to-spot lime green buses and for offering affordable transportation between cities in Europe and the Americas, Flixbus is a good option for those looking for an affordable, reliable bus company. In their buses, you'll find free WiFi, bathrooms, and power outlets. You can also pay extra to choose your seat and get extra legroom, or even buy a snack or drink onboard directly from the driver. You can reschedule your ticket for a small fee, which varies from $1 to $5, depending on how close you are to the departure date.

US bus companies: FlixBus, BlaBlaCar Bus, ALSA, Greyhound, Intercape, Trenitalia, Sindbad

Frequently asked questions about traveling from Indianapolis to Knoxville, TN by bus

What is the travel distance from Indianapolis to Knoxville?
What are the departure and arrival stations when taking the bus from Indianapolis to Knoxville?

Find cheapest prices for buses

Price is for a one-way ticket for one passenger and based on past searches.

Best price found

11/18

$119

11/19

$63

Today

$134

11/21

No data

11/22

No data

11/23

$99

11/24

No data

11/25

No data

The cheapest trip from Indianapolis to Knoxville, TN was searched and found on Nov 19, 2025 with a price of $63

To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Indianapolis to Knoxville, TN, as early as possible.

You can expect to pay from $63 to $181 for a bus ticket from Indianapolis to Knoxville, TN based on the last 2 days. You can expect to find the cheapest price for the trip at $99 which is on 2025-11-23.