How much is the bus ticket from Greenville to St. Louis?

The cheapest bus tickets from Greenville to St. Louis start from $124. The average price for this route is around $166. Busbud recommends that you book your tickets in advance for a better chance to get the lowest possible price.

How long is the bus ride from Greenville to St. Louis?

The average bus trip duration from Greenville to St. Louis is 1d 2h, covering a distance of 509 miles (821 km). The quickest bus can get you there in 14h 25m and is operated by FlixBus .

Which bus companies service the Greenville to St. Louis route?

Several major bus companies operate on this route with 2 buses available per day, including services from FlixBus , Greyhound .

What is the earliest and latest departure time for the bus from Greenville to St. Louis?

The earliest bus departs from Greenville to St. Louis at 2:45pm. And the latest bus departs at 10:00pm.

What are the CO₂ emissions for the bus trip from Greenville to St. Louis?

A bus trip from Greenville to St. Louis generates an estimated 21 kg of CO₂, making it a highly eco-friendly travel option and recommended mode of travel by Busbud.

What is the best bus company from Greenville to St. Louis?

According to Busbud customers, the highest-rated bus company on this route is FlixBus , with an average rating of 3.5 out of 5 stars based on 11828 reviews.

Which bus company has the best Wi-Fi from Greenville to St. Louis?

Based on reviews on Busbud, the bus company FlixBus has the best Wi-Fi rating with a score of 2.7.

Which bus company has the most timely service from Greenville to St. Louis?

According to Busbud traveller reviews, the most timely bus company on this route is FlixBus , with a punctuality rating of 3.9 out of 5 stars.

Which bus company has the cleanest buses from Greenville to St. Louis?

According to Busbud traveller reviews, the bus company with the cleanest buses on this route is FlixBus , with a cleanliness rating of 4.1 out of 5 stars.

Bus Greenville to St. Louis from $143 | Refundable Tickets

Previously seen trips

Next departures for Greenville to St. Louis on January 2
Operated by	Vehicle type	Departure time	Departure location	Trip duration	Arrival time	Arrival location	Recommended
Greyhound + FlixBus	Bus	7:45pm	1116 Woodruff Rd	22h 30m	5:15pm	Gateway Station	No tags
FlixBus + Greyhound	Bus	7:45pm	1116 Woodruff Rd	22h 30m	5:15pm	Gateway Station	No tags
FlixBus + Greyhound	Bus	12:15pm	1116 Woodruff Rd	1d 12h	11:35pm	Gateway Station	No tags
Greyhound + FlixBus	Bus	4:35pm	1116 Woodruff Rd	1d 14h	6:25am	Gateway Station	No tags
FlixBus + Greyhound	Bus	4:35pm	1116 Woodruff Rd	1d 14h	6:25am	Gateway Station	No tags

Compare 2 ways to go from Greenville to St. Louis

We recommend taking the bus

Among the sustainable travel choices, the bus stands out as the good way to reach St. Louis. The journey takes about 1 day, 2 hours and with fares starting at just $124, it presents an excellent value for a comfortable ride.

2bus per day

1d 2hAverage Duration

509 milesDistance

21kgCO₂ emissions

	Average Price	Average Duration	CO₂ emissions	Actions
Bus	Average Price$124 - $272	Average Duration1d 2h	CO₂ emissions 21kg CO₂e
Train	Average Price$417 - $586	Average Duration1d 17h	CO₂ emissions 74kg CO₂e

Where are the popular stops in Greenville and St. Louis?

Stops in Greenville

A
Guadalajara Supermarket Bus Stop
2803 White Horse Rd, Greenville, SC 29611
B
Greenville Bus Station
9 Hendrix DR, Greenville, SC 29607

Stops in St. Louis

A
Gateway Station
430 S 15th St, St Louis, MO 63103
Visit page

Compare bus companies

FlixBus

3.5/511,856 reviews

Staff4.1

Timeliness3.9

Cleanliness4.1

Wifi2.7

Flixbus is a European bus operator that offers intercity and bus travel in over 38 countries. Known for their easy-to-spot lime green buses and for offering affordable transportation between cities in Europe and the Americas, Flixbus is a good option for those looking for an affordable, reliable bus company. In their buses, you'll find free WiFi, bathrooms, and power outlets. You can also pay extra to choose your seat and get extra legroom, or even buy a snack or drink onboard directly from the driver. You can reschedule your ticket for a small fee, which varies from $1 to $5, depending on how close you are to the departure date.

Greyhound

3.5/587,472 reviews

Staff3.6

Timeliness2.9

Cleanliness3.3

Wifi2.4

Greyhound Lines offers the most comprehensive intercity bus services in the United States. They operate a modern, environmentally friendly fleet that serves more than 2400 destinations and carries nearly 16 million passengers annually. When traveling with them, you can expect free WiFi, onboard entertainment, bathrooms, power outlets and decent legroom. One of the great perks of Greyhound is that they connect big cities and smaller towns in the US, where you usually can't get to by train or plane. If you're looking for safe and affordable transportation, Greyhound is a great choice.

US bus companies:FlixBus, BlaBlaCar Bus, Greyhound, ALSA, Intercape, Trenitalia, Big Sky

Frequently asked questions about traveling from Greenville, SC to St. Louis by bus

Please note that schedules, routes, or operator details shown here may be updated or vary at the time of your trip.

How much is the bus ticket from Greenville to St. Louis?
The cheapest bus tickets from Greenville to St. Louis start from $124. The average price for this route is around $166. Busbud recommends that you book your tickets in advance for a better chance to get the lowest possible price.
How long is the bus ride from Greenville to St. Louis?
The average bus trip duration from Greenville to St. Louis is 1d 2h, covering a distance of 509 miles (821 km). The quickest bus can get you there in 14h 25m and is operated by FlixBus.
Which bus companies service the Greenville to St. Louis route?
Several major bus companies operate on this route with 2 buses available per day, including services from FlixBus, Greyhound.
What is the earliest and latest departure time for the bus from Greenville to St. Louis?
The earliest bus departs from Greenville to St. Louis at 2:45pm. And the latest bus departs at 10:00pm.
What are the CO₂ emissions for the bus trip from Greenville to St. Louis?
A bus trip from Greenville to St. Louis generates an estimated 21 kg of CO₂, making it a highly eco-friendly travel option and recommended mode of travel by Busbud.
What is the best bus company from Greenville to St. Louis?
According to Busbud customers, the highest-rated bus company on this route is FlixBus, with an average rating of 3.5 out of 5 stars based on 11828 reviews.
Which bus company has the best Wi-Fi from Greenville to St. Louis?
Based on reviews on Busbud, the bus company FlixBus has the best Wi-Fi rating with a score of 2.7.
Which bus company has the most timely service from Greenville to St. Louis?
According to Busbud traveller reviews, the most timely bus company on this route is FlixBus, with a punctuality rating of 3.9 out of 5 stars.
Which bus company has the cleanest buses from Greenville to St. Louis?
According to Busbud traveller reviews, the bus company with the cleanest buses on this route is FlixBus, with a cleanliness rating of 4.1 out of 5 stars.

Find cheapest prices for buses

Price is for a one-way ticket for one passenger and based on past searches.

Best price found

01/03

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01/04

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01/01

$121

Today

$143

The cheapest trip from Greenville, SC to St. Louis was searched and found on Jan 1, 2026 with a price of $121

To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Greenville, SC to St. Louis, as early as possible.

You can expect to pay from $121 to $177 for a bus ticket from Greenville, SC to St. Louis based on the last 1 days. You can expect to find the cheapest price for the trip at $177 which is on 2026-01-03.