Previously seen trips
| Operated by | Vehicle type | Departure time | Departure location | Trip duration | Arrival time | Arrival location | Recommended | Price and booking link |
|---|---|---|---|---|---|---|---|---|
FlixBus + Greyhound | Bus | Des Moines (Subway) | Charlotte (Uptown) | No tags | ||||
Greyhound + FlixBus | Bus | Des Moines (Subway) | Charlotte Bus Station | No tags | ||||
Greyhound + FlixBus | Bus | Des Moines (Subway) | Charlotte (Uptown) | No tags | ||||
Greyhound + FlixBus | Bus | Des Moines (Subway) | Charlotte (Freedom Dr) | No tags | ||||
FlixBus + Greyhound | Bus | Des Moines (Subway) | Charlotte Bus Station | No tags |
Get from Des Moines to Charlotte
The journey takes about 1 day, 8 hours 40 minutes and with fares starting at just $137, it presents an excellent value for a comfortable ride.
Compare bus companies
Greyhound Lines offers the most comprehensive intercity bus services in the United States. They operate a modern, environmentally friendly fleet that serves more than 2400 destinations and carries nearly 16 million passengers annually. When traveling with them, you can expect free WiFi, onboard entertainment, bathrooms, power outlets and decent legroom. One of the great perks of Greyhound is that they connect big cities and smaller towns in the US, where you usually can't get to by train or plane. If you're looking for safe and affordable transportation, Greyhound is a great choice.
Where are the popular stops in Des Moines and Charlotte?
Frequently asked questions about traveling from Des Moines to Charlotte, NC by bus
Find cheapest prices for buses
Price is for a one-way ticket for one passenger and based on past searches.
The cheapest trip from Des Moines to Charlotte, NC was searched and found on Nov 18, 2025 with a price of $129To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Des Moines to Charlotte, NC, as early as possible.
