Previously seen trips
| Operated by | Vehicle type | Departure time | Departure location | Trip duration | Arrival time | Arrival location | Recommended | Price and booking link |
|---|---|---|---|---|---|---|---|---|
 | Bus | Des Moines (Subway) | Detroit Bus Station | No tags | ||||
| Bus | Des Moines (Subway) | Detroit Bus Station | No tags | ||||
| Bus | Des Moines (Subway) | Detroit Bus Station | No tags | ||||
| Bus | Des Moines (Subway) | Detroit Bus Station | No tags | ||||
FlixBus + Greyhound | Bus | Des Moines (Subway) | Detroit Bus Station | No tags |
Get from Des Moines to Detroit
The journey takes about 16 hours 30 minutes and with fares starting at just $78, it presents an excellent value for a comfortable ride.
Compare bus companies
Greyhound Lines offers the most comprehensive intercity bus services in the United States. They operate a modern, environmentally friendly fleet that serves more than 2400 destinations and carries nearly 16 million passengers annually. When traveling with them, you can expect free WiFi, onboard entertainment, bathrooms, power outlets and decent legroom. One of the great perks of Greyhound is that they connect big cities and smaller towns in the US, where you usually can't get to by train or plane. If you're looking for safe and affordable transportation, Greyhound is a great choice.
Where are the popular stops in Des Moines and Detroit?
Frequently asked questions about traveling from Des Moines to Detroit, MI by bus
Find cheapest prices for buses
Price is for a one-way ticket for one passenger and based on past searches.
The cheapest trip from Des Moines to Detroit, MI was searched and found on Nov 17, 2025 with a price of $87To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Des Moines to Detroit, MI, as early as possible.
You can expect to pay from $87 to $89 for a bus ticket from Des Moines to Detroit, MI based on the last 2 days. You can expect to find the cheapest price for the trip at $89 which is on 2025-11-24.
