Next bus departures
| Operated by | Vehicle type | Departure time | Departure location | Trip duration | Arrival time | Arrival location | Recommended | Price and booking link |
|---|---|---|---|---|---|---|---|---|
 | Bus | DENVER | San Antonio Bus Station | CheapestFastest |
Last refresh of the prices: Yesterday at 7:42 PM MST.
Get from Denver to San Antonio
The journey takes about 21 hours 20 minutes and with fares starting at just $122, it presents an excellent value for a comfortable ride.
Where are the popular stops in Denver and San Antonio?
Stops in Denver
- A1701 Wynkoop St, Denver, CO 80202
- B
Bus Station
1055 19th St, Denver, CO 80202
Stops in San Antonio
- A500 N St Mary's St, San Antonio, TX 78205, USA
- B7914 Interstate 35 Access Rd, San Antonio, TX 78224, USA
- C165 Bowie St, San Antonio, 78205
- D4407 S PanAm Expy #101, San Antonio, TX 78225, USA
Compare bus companies
Greyhound Lines offers the most comprehensive intercity bus services in the United States. They operate a modern, environmentally friendly fleet that serves more than 2400 destinations and carries nearly 16 million passengers annually. When traveling with them, you can expect free WiFi, onboard entertainment, bathrooms, power outlets and decent legroom. One of the great perks of Greyhound is that they connect big cities and smaller towns in the US, where you usually can't get to by train or plane. If you're looking for safe and affordable transportation, Greyhound is a great choice.
Greyhound Denver San Antonio recent customer reviews
It delay the bus one day I couldn’t get my bus on the same day I was supposed to leave
Sergio G.
I was not told that I had to leave immediately and bus left without me in Amarillo. I had to wait for another bus and take a detour thru Dallas when I paid for a direct route ticket to Denver to San Antonio. It was a lot longer and no one seemed to care to communicate with me.
Austin F.
Bus driver was perfect as for as staff working there well it was very poor
Adam Jr. C.
Frequently asked questions about traveling from Denver to San Antonio, US by bus
Find cheapest prices for buses
Price is for a one-way ticket for one passenger and based on past searches.
The cheapest trip from Denver to San Antonio, US was searched and found on Nov 28, 2025 with a price of $181To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Denver to San Antonio, US, as early as possible.
You can expect to pay from $181 to $311 for a bus ticket from Denver to San Antonio, US based on the last 2 days. You can expect to find the cheapest price for the trip at $181 which is on 2025-11-28.
